Platelets serve as “first responders” during normal wounding and homeostasis. Arising from
bone marrow stem cell lineage megakaryocytes, anucleate platelets can influence …

We have established considerable expertise in studying the role of platelets in cancer
biology. From this expertise, we were keen to recognize the numerous venous-, arterial …

While blood clot formation has been relatively well studied, little is known about the
mechanisms underlying the subsequent structural and mechanical clot remodeling called …

Platelet adhesion and activation are essential initial processes of arterial and microvascular
hemostasis, where high hydrodynamic forces from the bloodflow impede coagulation. The …

Leaflet thrombosis following transcatheter aortic valve replacement (TAVR) and Valve-in-
Valve (ViV) procedures has been increasingly recognized. This study aimed to investigate …

We developed a novel data-driven Artificial Intelligence-enhanced Adaptive Time Stepping
algorithm (AI-ATS) that can adapt timestep sizes to underlying biophysical dynamics. We …

Using dissipative particle dynamics (DPD) combined with coarse grained molecular
dynamics (CGMD) approaches, we developed a multiscale deformable platelet model to …

The use of meshfree and particle methods in the field of bioengineering and biomechanics
has significantly increased. This may be attributed to their unique abilities to overcome most …

Recent advances in nanotechnology design and fabrication have shaped the landscape for
the development of ideal cell interfaces based on biomaterials. A holistic evaluation of the …

Both platelets and the liver play important roles in the processes of coagulation and innate
immunity. Platelet responses at the site of an injury are rapid; their immediate activation and …