The signaling lymphocyte activation molecule (SLAM)-associated protein, SAP, was first
identified as the protein affected in most cases of X-linked lymphoproliferative (XLP) …

In 2007, 1179 papers were published that involved the application of optical biosensors.
Reported developments in instrument hardware, assay design, and immobilization …

Measles virus, a major cause of childhood morbidity and mortality worldwide, predominantly
infects immune cells using signaling lymphocyte activation molecule (SLAM) as a cellular …

Genetic studies associate killer cell immunoglobulin-like receptors (KIRs) and their HLA
class I ligands with a variety of human diseases. The basis for these associations and the …

Natural killer (NK) cells possess potent cytolytic activity and secrete immune modulating
cytokines. The large repertoire of NK cell receptors provides versatility for the identification of …

The signaling lymphocytic activation molecule (SLAM) family of receptors and the SLAM-
associated protein (SAP) family of intracellular adaptors are expressed in immune cells. By …

The nine SLAM‐family genes, SLAMF1–9, a subfamily of the immunoglobulin superfamily,
encode differentially expressed cell‐surface receptors of hematopoietic cells. Engagement …

The majority of crystal structures are determined by the method of molecular replacement
(MR). The range of application of MR is limited mainly by the need for an accurate search …

The adaptors SAP, EAT-2 and ERT are specific to cells of the immune system and belong to
the SAP family. All three are expressed in natural killer (NK) cells. Here we examined the …

Abstract 2B4 belongs to the CD2 family of molecules and is expressed on all NK, γδ, and
memory CD8+(αβ) T cells. The murine NK receptor 2B4 exhibits both inhibitory and …