The pros and cons of mesenchymal stem cell-based therapies

A Musiał-Wysocka, M Kot, M Majka - Cell transplantation, 2019 - journals.sagepub.com
The need to search for new, alternative treatments for various diseases has prompted
scientists and physicians to focus their attention on regenerative medicine and broadly …

Mesenchymal stem cells for chronic wound healing: current status of preclinical and clinical studies

YZ Huang, M Gou, LC Da, WQ Zhang… - Tissue Engineering Part …, 2020 - liebertpub.com
Healing skin wounds with anatomic and functional integrity, especially under chronic
pathological conditions, remain an enormous challenge. Due to their outstanding …

[HTML][HTML] Mesenchymal stem/stromal cell-derived exosomes in regenerative medicine and cancer; overview of development, challenges, and opportunities

A Hassanzadeh, HS Rahman, A Markov… - Stem cell research & …, 2021 - Springer
Recently, mesenchymal stem/stromal cells (MSCs) and their widespread biomedical
applications have attracted great consideration from the scientific community around the …

[HTML][HTML] Mesenchymal stem cell–derived extracellular vesicles attenuate kidney inflammation

A Eirin, XY Zhu, AS Puranik, H Tang, KA McGurren… - Kidney international, 2017 - Elsevier
Mesenchymal stem/stromal cells (MSCs) have distinct capability for renal repair, but may
have safety concerns. MSC-derived extracellular vesicles emerged as a novel noncellular …

[PDF][PDF] Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis

NB Leimkühler, HFE Gleitz, L Ronghui, IAM Snoeren… - Cell Stem Cell, 2021 - cell.com
Functional contributions of individual cellular components of the bone-marrow
microenvironment to myelofibrosis (MF) in patients with myeloproliferative neoplasms …

[HTML][HTML] Exosomes/microvesicles as a mechanism of cell-to-cell communication

G Camussi, MC Deregibus, S Bruno, V Cantaluppi… - Kidney international, 2010 - Elsevier
Microvesicles (MVs) are circular fragments of membrane released from the endosomal
compartment as exosomes or shed from the surface membranes of most cell types. An …

Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia–reperfusion-induced acute and chronic kidney injury

S Gatti, S Bruno, MC Deregibus, A Sordi… - Nephrology Dialysis …, 2011 - academic.oup.com
Background. Several studies demonstrated that mesenchymal stem cells (MSCs) reverse
acute kidney injury (AKI) by a paracrine mechanism rather than by MSC transdifferentiation …

Mesenchymal stem cell-derived microvesicles protect against acute tubular injury

S Bruno, C Grange, MC Deregibus… - Journal of the …, 2009 - journals.lww.com
Administration of mesenchymal stem cells (MSCs) improves the recovery from acute kidney
injury (AKI). The mechanism may involve paracrine factors promoting proliferation of …

Mesenchymal stem cells as therapeutics

B Parekkadan, JM Milwid - Annual review of biomedical …, 2010 - annualreviews.org
Mesenchymal stem cells (MSCs) are multipotent cells that are being clinically explored as a
new therapeutic for treating a variety of immune-mediated diseases. First heralded as a …

Therapeutic potential of mesenchymal stem cell-derived microvesicles

L Biancone, S Bruno, MC Deregibus… - Nephrology Dialysis …, 2012 - academic.oup.com
Several studies have demonstrated that mesenchymal stem cells have the capacity to
reverse acute and chronic kidney injury in different experimental models by paracrine …