For nearly 50 years the proximal tubule (PT) has been known to reabsorb, process, and
either catabolize or transcytose albumin from the glomerular filtrate. Innovative techniques …

Kidney stones (also known as urinary stones or nephrolithiasis) are highly prevalent,
affecting approximately 10% of adults worldwide, and the incidence of stone disease is …

CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …

About 5% of American women and 12% of men will develop a kidney stone at some time in
their life, and prevalence has been rising in both sexes. Approximately 80% of stones are …

Cl− channels reside both in the plasma membrane and in intracellular organelles. Their
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …

Recent data highlight the role of the proximal tubule (PT) in reabsorbing, processing, and
transcytosing urinary albumin from the glomerular filtrate. Innovative techniques and …

Adenine phosphoribosyltransferase (APRT) deficiency, cystinuria, Dent disease, familial
hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC), and primary …

Membrane trafficking pathways are essential for the viability and growth of cells, and play a
major role in the interaction of cells with their environment. In this At a Glance article and …

Receptor-mediated endocytosis is responsible for protein reabsorption in the proximal
tubule. This process involves two interacting receptors, megalin and cubilin, which form a …

Vitelliform macular dystrophy (VMD/Best disease; MIM* 153700) is an early-onset autosomal
dominant disorder in which accumulation of lipofuscin-like material within and beneath the …