ATP is a (co) transmitter and signaling molecule in the CNS. It acts at a multitude of ligand-
gated cationic channels termed P2X to induce rapid depolarization of the cell membrane …

Alzheimer´ s disease (AD) is a neurodegenerative disorder with no known cure and rapid
rise in incidence. The predominant cognitive impairment is currently treated using cognitive …

The initiation and progression of Alzheimer disease (AD) is a complex process not yet fully
understood. While many hypotheses have been provided as to the cause of the disease, the …

Alzheimer's disease (AD) is a progressive, irreversible brain disorder characterized by
pathological aggregation of the amyloid-β peptide (Aβ) and tau protein; both of these are …

The kinetics of amyloid beta turnover within human brain is still poorly understood. We
previously found a dramatic decline in the turnover of Aβ peptides in normal aging. It was not …

Cerebrospinal fluid and positron emission tomography biomarkers accurately predict an
underlying Alzheimer's disease (AD) pathology; however, they represent either invasive or …

Despite the acceleration of knowledge and data accumulation in neuroscience over the last
years, the highly prevalent neurodegenerative disease of AD remains a growing problem …

Extracellular exosomes are formed inside the cytoplasm of cells in compartments known as
multivesicular bodies. Thus, exosomes contain cytoplasmic content. Multivesicular bodies …

Mitochondrial dysfunction is one of the basic hallmarks of cellular pathology in
neurodegenerative diseases. Since the metabolic activity of neurons is highly dependent on …

The lack of standardization in the way that quantitative and systems pharmacology (QSP)
models are developed, tested, and documented hinders their reproducibility, reusability, and …