Keratins—types I and II—are the intermediate-filament-forming proteins expressed in
epithelial cells. They are encoded by 54 evolutionarily conserved genes (28 type I, 26 type …

For a protein to function appropriately, it must first achieve its proper conformation and
location within the crowded environment inside the cell. Multiple chaperone systems are …

The cytoplasm is the largest part of the cell by volume and hence its rheology sets the rate at
which cellular shape changes can occur. Recent experimental evidence suggests that …

The coordinated interplay of cytoskeletal networks critically determines tissue biomechanics
and structural integrity. Here, we show that plectin, a major intermediate filament-based …

Intermediate filaments provide scaffolding for the cell and protect it against stress. This
comprehensive review points out that there are more than 100 intermediate filament genes …

p53 is a master regulatory protein that participates in cellular processes such as apoptosis,
DNA repair, and cell cycle control. p53 functions as a homotetrameric tumor suppressor, and …

Intermediate filaments (IFs) are cytoskeletal polymers whose protein constituents are
encoded by a large family of differentially expressed genes. Owing in part to their properties …

The diversity of epithelial functions is reflected by the expression of distinct keratin pairs that
are responsible to protect epithelial cells against mechanical stress and to act as signaling …

Epithelia are exposed to multiple forms of stress. Keratin intermediate filaments are
abundant in epithelia and form cytoskeletal networks that contribute to cell type–specific …

Epidermolysis bullosa (EB) simplex is a rare genetic condition typified by superficial bullous
lesions that result from frictional trauma to the skin. Most cases are due to dominantly acting …