Descending control of pain
MJ Millan - Progress in neurobiology, 2002 - Elsevier
Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …
information from the viscera, skin and other organs is subject to extensive processing by a …
Receptors for purines and pyrimidines
V Ralevic, G Burnstock - Pharmacological reviews, 1998 - ASPET
Extracellular purines (adenosine, ADP, and ATP) and pyrimidines (UDP and UTP) are
important signaling molecules that mediate diverse biological effects via cellsurface …
important signaling molecules that mediate diverse biological effects via cellsurface …
International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors
BB Fredholm, AP IJzerman, KA Jacobson… - Pharmacological …, 2001 - ASPET
Four adenosine receptors have been cloned and characterized from several mammalian
species. The receptors are named adenosine A1, A2A, A2B, and A3. The A2A and A2B …
species. The receptors are named adenosine A1, A2A, A2B, and A3. The A2A and A2B …
Adenosine receptors as therapeutic targets
KA Jacobson, ZG Gao - Nature reviews Drug discovery, 2006 - nature.com
Adenosine receptors are major targets of caffeine, the most commonly consumed drug in the
world. There is growing evidence that they could also be promising therapeutic targets in a …
world. There is growing evidence that they could also be promising therapeutic targets in a …
The A3 adenosine receptor: history and perspectives
By general consensus, the omnipresent purine nucleoside adenosine is considered a major
regulator of local tissue function, especially when energy supply fails to meet cellular energy …
regulator of local tissue function, especially when energy supply fails to meet cellular energy …
Resident cardiac mast cells degranulate and release preformed TNF-α, initiating the cytokine cascade in experimental canine myocardial ischemia/reperfusion
NG Frangogiannis, ML Lindsey, LH Michael… - Circulation, 1998 - Am Heart Assoc
Background—Neutrophil-induced cardiomyocyte injury requires the expression of myocyte
intercellular adhesion molecule (ICAM)-1 and ICAM-1–CD11b/CD18 adhesion. We have …
intercellular adhesion molecule (ICAM)-1 and ICAM-1–CD11b/CD18 adhesion. We have …
Inflammatory mediators of asthma: an update
Asthma is a complex chronic inflammatory disease of the airways that involves the activation
of many inflammatory and structural cells, all of which release inflammatory mediators that …
of many inflammatory and structural cells, all of which release inflammatory mediators that …
Synaptic control of motoneuronal excitability
Movement, the fundamental component of behavior and the principal extrinsic action of the
brain, is produced when skeletal muscles contract and relax in response to patterns of action …
brain, is produced when skeletal muscles contract and relax in response to patterns of action …
Tissue distribution of adenosine receptor mRNAs in the rat
AK Dixon, AK Gubitz, DJS Sirinathsinghji… - British journal of …, 1996 - Wiley Online Library
1 A degree of ambiguity and uncertainty exists concerning the distribution of mRNAs
encoding the four cloned adenosine receptors. In order to consolidate and extend current …
encoding the four cloned adenosine receptors. In order to consolidate and extend current …
Signalling from adenosine receptors to mitogen-activated protein kinases
G Schulte, BB Fredholm - Cellular signalling, 2003 - Elsevier
The purine nucleoside adenosine acts via four distinct adenosine receptor subtypes: the
adenosine A1, A2A, A2B, and A3 receptor. They are all G protein-coupled receptors (GPCR) …
adenosine A1, A2A, A2B, and A3 receptor. They are all G protein-coupled receptors (GPCR) …