Over the last decade, the zebrafish has entered the field of cardiovascular research as a
new model organism. This is largely due to a number of highly successful small-and large …

TGF-β superfamily signaling pathways emerged with the evolution of multicellular animals,
suggesting that these pathways contribute to the increased diversity and complexity required …

Recent findings indicate that specific microRNAs (miRNAs), such as those of the miR-17-92
cluster, may be responsible for regulating endothelial gene expression during tumor …

Evolutionarily conserved signaling pathways are essential for early embryogenesis, and
reducing or abolishing their activity leads to characteristic developmental defects …

Information on the ontogeny of the fish immune system is largely restricted to a few species
of teleosts (eg, rainbow trout, catfish, zebrafish, sea bass) and has previously focused on …

The lateral plate mesoderm (LPM) forms the progenitor cells that constitute the heart and
cardiovascular system, blood, kidneys, smooth muscle lineage and limb skeleton in the …

Neural induction represents the earliest step in the determination of ectodermal cell fates. In
vertebrates, bone morphogenetic proteins (BMPs) act as signals of epidermal induction. The …

Hematopoietic stem cells (HSCs) are thought to arise in the aorta-gonad-mesonephros
(AGM) region of embryo proper, although HSC activity can be detected in yolk sac (YS) and …

Forward-genetic analyses in Drosophila and Caenorhabditis elegans have given us
unprecedented insights into many developmental mechanisms. To study the formation of …

The bone morphogenetic proteins (BMPs) are a group of powerful morphogens that are
critical for development of the nervous system. The effects of BMP signaling on neural stem …