The great plasticity of Schwann cells (SCs), the myelinating glia of the peripheral nervous
system (PNS), is a critical feature in the context of peripheral nerve regeneration following …

The remarkable plasticity of Schwann cells allows them to adopt the Remak (non-myelin)
and myelin phenotypes, which are specialized to meet the needs of small and large …

Nerve injury triggers the conversion of myelin and non‐myelin (Remak) Schwann cells to a
cell phenotype specialized to promote repair. Distal to damage, these repair Schwann cells …

Schwann cells respond to nerve injury by cellular reprogramming that generates cells
specialized for promoting regeneration and repair. These repair cells clear redundant …

Schwann cells develop from the neural crest in a well-defined sequence of events. This
involves the formation of the Schwann cell precursor and immature Schwann cells, followed …

Myelination of axons in the nervous system of vertebrates enables fast, saltatory impulse
propagation, one of the best-understood concepts in neurophysiology. However, it took a …

Rodent models of nerve injury have increased our understanding of peripheral nerve
regeneration, but clinical applications have been scarce, partly because such models do not …

Schwann cell dedifferentiation from a myelinating to a progenitor-like cell underlies the
remarkable ability of peripheral nerves to regenerate following injury. However, the …

Although Schwann cell myelin breakdown is the universal outcome of a remarkably wide
range of conditions that cause disease or injury to peripheral nerves, the cellular and …

The radical response of peripheral nerves to injury (Wallerian degeneration) is the
cornerstone of nerve repair. We show that activation of the transcription factor c-Jun in …