Modulation of innate and adaptive immunity by cytomegaloviruses
The coordinated activities of innate and adaptive immunity are critical for effective protection
against viruses. To counter this, some viruses have evolved sophisticated strategies to …
against viruses. To counter this, some viruses have evolved sophisticated strategies to …
[HTML][HTML] Human cytomegalovirus in cancer: The mechanism of HCMV-induced carcinogenesis and its therapeutic potential
C Yu, S He, W Zhu, P Ru, X Ge… - Frontiers in Cellular …, 2023 - ncbi.nlm.nih.gov
Cancer is one of the leading causes of death worldwide. Human cytomegalovirus (HCMV), a
well-studied herpesvirus, has been implicated in malignancies derived from breast …
well-studied herpesvirus, has been implicated in malignancies derived from breast …
Role of PDGF receptor-α during human cytomegalovirus entry into fibroblasts
K Wu, A Oberstein, W Wang… - Proceedings of the …, 2018 - National Acad Sciences
Human CMV (HCMV) exhibits a broad cell tropism that depends on two virion glycoprotein
complexes: a trimeric complex (gH/gL/gO) that facilitates viral infection primarily in …
complexes: a trimeric complex (gH/gL/gO) that facilitates viral infection primarily in …
The pentameric complex drives immunologically covert cell–cell transmission of wild-type human cytomegalovirus
I Murrell, C Bedford, K Ladell… - Proceedings of the …, 2017 - National Acad Sciences
Human cytomegalovirus (HCMV) strains that have been passaged in vitro rapidly acquire
mutations that impact viral growth. These laboratory-adapted strains of HCMV generally …
mutations that impact viral growth. These laboratory-adapted strains of HCMV generally …
ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways
A Rubina, M Patel, K Nightingale… - Proceedings of the …, 2023 - National Acad Sciences
Human cytomegalovirus (HCMV) is a major human pathogen whose life-long persistence is
enabled by its remarkable capacity to systematically subvert host immune defenses. In …
enabled by its remarkable capacity to systematically subvert host immune defenses. In …
Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation
CA Fielding, MP Weekes, LV Nobre, E Ruckova… - Elife, 2017 - elifesciences.org
The human cytomegalovirus (HCMV) US12 family consists of ten sequentially arranged
genes (US12-21) with poorly characterized function. We now identify novel natural killer …
genes (US12-21) with poorly characterized function. We now identify novel natural killer …
Human cytomegalovirus genomics and transcriptomics through the lens of next-generation sequencing: revision and future challenges
J Martí-Carreras, P Maes - Virus Genes, 2019 - Springer
The human cytomegalovirus (HCMV) genome was sequenced by hierarchical shotgun
almost 30 years ago. Over these years, low and high passaged strains have been …
almost 30 years ago. Over these years, low and high passaged strains have been …
Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses
ECY Wang, M Pjechova… - Proceedings of the …, 2018 - National Acad Sciences
CD58 is an adhesion molecule that is known to play a critical role in costimulation of effector
cells and is intrinsic to immune synapse structure. Herein, we describe a virally encoded …
cells and is intrinsic to immune synapse structure. Herein, we describe a virally encoded …
Real-time visualization and quantification of human cytomegalovirus replication in living cells using the ANCHOR DNA labeling technology
B Mariamé, S Kappler-Gratias, M Kappler… - Journal of …, 2018 - Am Soc Microbiol
Human cytomegalovirus (HCMV) induces latent lifelong infections in all human populations.
Between 30% and nearly 100% of individuals are affected depending on the geographic …
Between 30% and nearly 100% of individuals are affected depending on the geographic …
Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus
VM Vlahava, I Murrell, L Zhuang… - The Journal of …, 2021 - Am Soc Clin Investig
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that causes severe disease
following congenital infection and in immunocompromised individuals. No vaccines are …
following congenital infection and in immunocompromised individuals. No vaccines are …