The endoplasmic reticulum (ER) has recently emerged as a promising target for anticancer
agents. Cytotoxic compounds that target the ER often exhibit selectivity for cancer cells over …

A plethora of studies indicate that iron metabolism is dysregulated in Parkinson's disease
(PD). The literature reveals well-documented alterations consistent with established dogma …

Significance: During the past decades, thiosemicarbazones were clinically developed for a
variety of diseases, including tuberculosis, viral infections, malaria, and cancer. With regard …

Background The incidence of colorectal cancer and cancer death rate are increasing every
year, and the affected population is becoming younger. Traditional Chinese medicine …

Iron metabolism and tumor biology are intimately linked. Iron facilitates the production of
oxygen radicals, which may either result in iron-induced cell death, ferroptosis, or contribute …

Six morpholine-(iso) thiosemicarbazone hybrids HL 1–HL 6 and their Cu (II) complexes with
good-to-moderate solubility and stability in water were synthesized and characterized. Cu …

Background: Cancer accounts for several deaths each year. There are multiple FDA
approved drugs for cancer treatments. Due to the severe side effects and multiple drug …

This study was conducted to understand the effect of high-fat diet challenge on lipid
transport and endoplasmic reticulum stress in blunt snout bream. Ninety fish (average …

Background The development of potent non-toxic chemotherapeutic drugs against
castration resistant prostate cancer (CRPC) remains a major challenge. Corosolic acid (CA) …

N-myc downstream regulated gene-1 (NDRG1) is a potent metastasis suppressor that is
regulated by hypoxia, metal ions including iron, the free radical nitric oxide (NO.), and …