Background The roles of host and pathogen factors in determining innate immune
responses to M. tuberculosis are not fully understood. In this study, we examined host …

Tuberculosis has been a public health crisis since the 1900, which has caused the highest
mortalities due to a single bacterial infection worldwide, that was recently further …

We demonstrate how a single universal spinach aptamer (USSA) probe can be used to
detect multiple (potentially any) nucleic acid sequences. USSA can be used for cost-efficient …

The interaction between pattern-recognition receptors (PRRs) and pathogen-associated
molecular patterns (PAMPs) induces type I interferon (IFN) responses. IFNs stimulates …

Many studies have identified host-derived lipids, characterised by the abundance of
cholesterol, as a major source of carbon nutrition for Mycobacterium tuberculosis during …

Abstract M. tuberculosis F15/LAM4/KZN has been associated with high transmission rates of
drug resistant tuberculosis in the KwaZulu-Natal province of South Africa. The current study …

Host cytoplasmic surveillance pathways are known to elicit type I interferon (IFN) responses
which are crucial to antimicrobial defense mechanisms. Oligoadenylate synthetase-like …

The World Health Organisation (WHO) estimated 1.2 million deaths as well as 10 million
new tuberculosis (TB) infections annually (WHO, 2019). High transmission and persistence …

Tuberculosis, caused by Mycobacterium tuberculosis, is a leading cause of infectious
mortality. It affects humans and other mammals, including cattle, with significant health …

Tuberculosis affects human life globally for long time. About one third of the world's
population is infected with the causal pathogen Mycobacterium tuberculosis but without …