Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …

Chromosome congression during prometaphase culminates with the establishment of a
metaphase plate, a hallmark of mitosis in metazoans. Classical views resulting from more …

Summary The Mad1-Mad2 heterodimer is the catalytic hub of the spindle assembly
checkpoint (SAC), which controls M phase progression through a multi-subunit anaphase …

Faithful chromosome segregation depends on the ability of sister kinetochores to attach to
spindle microtubules. The outer layer of kinetochores transiently expands in early mitosis to …

The molecular motor dynein concentrates at the kinetochore region of mitotic chromosomes
in animals to accelerate spindle microtubule capture and to control spindle checkpoint …

Cytoplasmic Dynein 1, or Dynein, is a microtubule minus end–directed motor. Dynein
motility requires Dynactin and a family of activating adaptors that stabilize the Dynein …

The microtubule minus-end-directed motility of cytoplasmic dynein 1 (dynein), arguably the
most complex and versatile cytoskeletal motor, is harnessed for diverse functions, such as …

Chromosome segregation during mitosis is highly regulated to ensure production of
genetically identical progeny. Recurrent mitotic errors cause chromosomal instability (CIN) …

Faithful chromosome segregation during mitosis in eukaryotes requires attachment of the
kinetochore, a large protein complex assembled on the centromere of each chromosome, to …

In metazoans, a≈ 1 megadalton (MDa) multiprotein complex comprising the dynein–
dynactin adaptor Spindly and the ROD–Zwilch–ZW10 (RZZ) complex is the building block of …