Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …

Reactive oxygen species (ROS) are known mediators of intracellular signaling cascades.
Excessive production of ROS may, however, lead to oxidative stress, loss of cell function …

Thioredoxin and glutaredoxin systems in mammalian cells utilize thiol and selenol groups to
maintain a reducing intracellular redox state acting as antioxidants and reducing agents in …

The thioredoxin (Trx) system comprises Trx, truncated Trx (Trx-80), Trx reductase, and
NADPH, besides a natural Trx inhibitor, the thioredoxin-interacting protein (TXNIP). This …

Since their discovery as a substrate for ribonucleotide reductase (RNR), the role of
thioredoxin (Trx) and glutaredoxin (Grx) has been largely extended through their regulatory …

Most of the examples of protein translocation across a membrane (such as the import of
classical secretory proteins into the endoplasmic reticulum, import of proteins into …

Atherosclerosis is a leading cause of cardiovascular diseases (CVD) worldwide and
intimately linked to aging. This pathology is characterized by chronic inflammation, oxidative …

It has been shown that thioredoxin (Trx) in a reduced form binds to and inhibits apoptosis
signal-regulating kinase 1 (ASK1). Apoptotic stimuli such as tumor necrosis factor (TNF) and …

The classical secretion of soluble proteins and transport of integral membrane proteins to
the cell surface require transit into and through the endoplasmic reticulum and the Golgi …

To identify proteins undergoing glutathionylation (formation of protein-glutathione mixed
disulfides) in human T cell blasts, we radiolabeled the glutathione pool with 35S, exposed …