Paradigm shifts in surgery arise when surgeons are empowered to perform surgery faster,
better and less expensively than current standards. Optical imaging that exploits invisible …

Spatial frequency domain imaging (SFDI) has witnessed very rapid growth over the last
decade, owing to its unique capabilities for imaging optical properties and chromophores …

The authors describe the development of diffuse optical imaging (DOI) technologies,
specifically the use of spatial and temporal modulation to control near infrared light …

The emerging clinical use of targeted fluorescent agents heralds a shift in intraoperative
imaging practices that overcome the limitations of human vision. However, in contrast to …

This is the third part of the review-tutorial paper describing fundamentals of tissue optics and
photonics. The first part of the paper was mostly devoted to description of tissue structures …

Determination of chemotherapy efficacy early during treatment would provide more
opportunities for physicians to alter and adapt treatment plans. Diffuse optical technologies …

Rationale and Objectives The treatment of nonmelanoma skin cancer (NMSC) is usually by
surgical excision or Mohs micrographic surgery and alternatively may include photodynamic …

Photodynamic therapy (PDT) is a treatment modality that uses a specific photosensitizing
agent, molecular oxygen, and light of a particular wavelength to kill cells targeted by the …

Spatial frequency domain imaging (SFDI) is a widefield imaging technique that allows for the
quantitative extraction of tissue optical properties. SFDI is currently being explored for small …

Fluorescence imaging is well suited to provide image guidance during resections in
oncologic and vascular surgery. However, the distorting effects of tissue optical properties …