Background Zika virus (ZIKV) is an emerging flavivirus of global concern. ZIKV infection of
the central nervous system has been linked to a variety of clinical syndromes, including …

Viral tropism within the brain and the role (s) of vertebrate immune response to neurotropic
flaviviruses infection is largely understudied. We combine multimodal imaging (cm-nm …

Introduction Naturally attenuated Langat virus (LGTV) and highly pathogenic tick-borne
encephalitis virus (TBEV) share antigenically similar viral proteins and are grouped together …

Powassan infection is caused by two closely related, tick-transmitted viruses of the genus
Flavivirus (family Flaviviridae): Powassan virus lineage I (POWV) and lineage II (known as …

Neurotropic viruses target the brain and contribute to neurologic diseases. Caspase
recruitment domain containing family member 9 (CARD9) controls protective immunity in a …

The hypothalamic molecular processes participate in the regulation of the neuro-immune-
endocrine system, including hormone, metabolite, chemokine circulation, and …

Abstract Background Borna disease virus 1 (BoDV-1) is a non-segmented, negative-strand
RNA virus that persistently infects mammals including humans. BoDV-1 worldwide occurring …

Neurotropic viruses target the brain and contribute to neurologic diseases. C-type lectin
receptors (CLRs) are pattern recognition receptors that recognize carbohydrate structures …

Serine proteinase inhibitors (serpins), identified from the hard tick Haemaphysalis
longicornis of China, play significant roles in various animal physiological processes. In this …

Tick-borne encephalitis virus (TBEV) is a leading cause of vector-borne viral encephalitis
with expanding endemic regions across Europe. In this study we tested in mice the efficacy …