In vertebrates, double-strand breaks in DNA are primarily repaired by Non-Homologous End-
Joining (NHEJ). The ring-shaped Ku heterodimer rapidly senses and threads onto broken …

Lymphocyte development requires ordered assembly and subsequent modifications of the
antigen receptor genes through V (D) J recombination and Immunoglobulin class switch …

Nonhomologous end joining is a critical mechanism that repairs DNA double-strand breaks
in human cells. In this work, we address the structural and functional role of the accessory …

V (D) J recombination is an essential mechanism of the adaptive immune system, producing
a diverse set of antigen receptors in developing lymphocytes via regulated double strand …

DNA double‐strand breaks (DSBs) are highly cytotoxic lesions, and unrepaired or
misrepaired DSBs can lead to various human diseases, including immunodeficiency …

Antigen receptor diversification is a hallmark of adaptive immunity which allows specificity of
the receptor to particular antigen. B cell receptor (BCR) or its secreted form, antibody, is …

Non-homologous end joining (cNHEJ) is a major pathway to repair double-strand breaks
(DSBs) in DNA. Several core cNHEJ are involved in the progress of the repair such as KU70 …

Non‐homologous end joining (NHEJ) is the main DNA repair mechanism for the repair of
double‐strand breaks (DSBs) throughout the course of the cell cycle. DSBs are generated in …

Non-homologous end joining (NHEJ) is a DNA repair pathway that senses, processes and
ligates DNA double-strand breaks (DSBs) throughout the cell cycle. During NHEJ, core …

To ensure genome stability, mammalian cells employ several DNA repair pathways.
Nonhomologous DNA end joining (NHEJ) is the DNA repair process that fixes double …