Mitochondria are the cells' powerhouse, but also their suicidal weapon store. Dozens of
lethal signal transduction pathways converge on mitochondria to cause the permeabilization …

Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

The accumulation of Ca 2+ in the mitochondrial matrix can stimulate oxidative
phosphorylation, but can also, at high Ca 2+ concentrations, transmit and amplify an …

Apoptosis has been causally linked to the pathogenesis of myocardial infarction and heart
failure in rodent models. This death process is mediated by two central pathways, an …

Mitochondrial permeability transition (MPT) is the sudden loss in the permeability of the
inner mitochondrial membrane (IMM) to low-molecular-weight solutes. Due to osmotic …

In addition to its normal function, the adenine nucleotide translocase (ANT) forms the inner
membrane channel of the mitochondrial permeability transition pore (MPTP). Binding of …

Anti-apoptotic Bcl2 family proteins such as Bcl-xL protect cells from death by sequestering
apoptotic molecules, but also contribute to normal neuronal function. We find in …

Abstract Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a pleiotropic enzyme that
is overexpressed in apoptosis and in several human chronic pathologies. Here, we report …

Mitochondrial dysfunction is an underlying cause of ischemia-reperfusion injury. In
particular, ischemic injury induces dramatic increases in mitochondrial permeability, thereby …

After antigen-driven expansion, the majority of T cells involved in an immune response die
rapidly by apoptosis dependent on the Bcl-2 related proteins, Bim and Bax or Bak. The …