Cyclic ion mobility–collision activation experiments elucidate protein behavior in the gas phase
Ion mobility coupled to mass spectrometry (IM-MS) is widely used to study protein dynamics
and structure in the gas phase. Increasing the energy with which the protein ions are …
and structure in the gas phase. Increasing the energy with which the protein ions are …
Interspecies Variation Affects Islet Amyloid Polypeptide Membrane Binding
HM Sanders, F Chalyavi, CR Fields… - Journal of the …, 2023 - ACS Publications
The aggregation of islet amyloid polypeptide (IAPP) is associated with β-cell dysfunction in
type 2 diabetes (T2D) in humans. One possible mechanism of toxicity is the interaction of …
type 2 diabetes (T2D) in humans. One possible mechanism of toxicity is the interaction of …
Differential effects of aromatic residues on amyloid formation and cytotoxicity of human IAPP
L Manathunga, A Zhyvoloup, A Baghai… - Biochemistry, 2022 - ACS Publications
Islet amyloid polypeptide (IAPP) is a 37-residue polypeptide hormone secreted by the
pancreatic β-cells. IAPP plays a role in glycemic regulation, but in the pre-type-2 diabetic …
pancreatic β-cells. IAPP plays a role in glycemic regulation, but in the pre-type-2 diabetic …
Contribution of the 12–17 hydrophobic region of islet amyloid polypeptide in self-assembly and cytotoxicity
M Fortier, M Côté-Cyr, V Nguyen, M Babych… - Frontiers in Molecular …, 2022 - frontiersin.org
The islet amyloid polypeptide (IAPP) is a 37-residue aggregation-prone peptide hormone
whose deposition as insoluble fibrils in the islets of Langerhans is associated with type II …
whose deposition as insoluble fibrils in the islets of Langerhans is associated with type II …
On the importance of being amidated: Analysis of the role of the conserved C-terminal amide of amylin in amyloid formation and cytotoxicity
T Yang, I Filippov, L Manathunga, A Baghai… - Biophysical …, 2024 - Elsevier
The polypeptide hormone Amylin (also known as islet amyloid polypeptide) plays a role in
regulation of glucose metabolism, but forms pancreatic islet amyloid deposits in type 2 …
regulation of glucose metabolism, but forms pancreatic islet amyloid deposits in type 2 …
Conformation-reconstructed multivalent antibody mimic for amplified mitigation of human islet amyloid polypeptide amyloidogenesis
L Zhao, S Wang, Q Hu, H Jia, Y Xin, L Luo, F Meng - Nanoscale, 2022 - pubs.rsc.org
The misfolding and aggregation of human islet amyloid polypeptide (IAPP) into β-sheet-
enriched amyloid fibrils is linked to type 2 diabetes. Antibodies are potent inhibitors of IAPP …
enriched amyloid fibrils is linked to type 2 diabetes. Antibodies are potent inhibitors of IAPP …
Novel amylin analogues reduce amyloid-β cross-seeding aggregation and neurotoxicity
GL Dharmaraj, FD Arigo, KA Young… - Journal of …, 2022 - content.iospress.com
Background: Type 2 diabetes related human islet amyloid polypeptide (hIAPP) plays a dual
role in Alzheimer's disease (AD). hIAPP has neuroprotective effects in AD mouse models …
role in Alzheimer's disease (AD). hIAPP has neuroprotective effects in AD mouse models …
Understanding the mechanism of amylin aggregation: From identifying crucial segments to tracing dominant sequential events to modeling potential aggregation …
R Ghosh, S Ghosh, A Das - Biochimica et Biophysica Acta (BBA)-Proteins …, 2023 - Elsevier
One of the most abundant, prevailing, and life-threatening human diseases that are currently
baffling the scientific community is type 2 diabetes (T2D). The self-association of human …
baffling the scientific community is type 2 diabetes (T2D). The self-association of human …
Deciphering the impact of F23L mutation on the aggregation propensity of human islet amyloid polypeptide using molecular simulations
A Manchanda, B Goyal - Journal of Molecular Liquids, 2024 - Elsevier
The self-aggregation of 37-residue human islet amyloid polypeptide (hIAPP) into β-sheet
rich oligomers and amyloid fibrils contributes to the loss of pancreatic β-cell mass in type 2 …
rich oligomers and amyloid fibrils contributes to the loss of pancreatic β-cell mass in type 2 …
Analysis of sheep and goat IAPP provides insight into IAPP amyloidogenicity and cytotoxicity
MET Miller, MH Li, A Baghai, VH Peetz… - Biochemistry, 2022 - ACS Publications
Human islet amyloid polypeptide (hIAPP) plays a role in glucose regulation but forms
pancreatic amyloid deposits in type 2 diabetes, and that process contributes to β-cell …
pancreatic amyloid deposits in type 2 diabetes, and that process contributes to β-cell …