Natural killer (NK) cells are part of the innate-immune system and respond rapidly to a
variety of insults via cytokine secretion and cytolytic activity. Their main function is first line of …

Psoriasis is a chronic condition of the skin characterised by distinctive scaly plaques. The
immune system is now thought to play a major role in the development and pathogenesis of …

Psoriasis is characterized by a dermal and epidermal infiltrate comprised predominantly of
CD4+ and CD8+ T cells, respectively. These cells behave in an antigen-dependent manner …

Psoriasis is a heterogeneous disease with seven major psoriasis susceptibility loci reported
so far on chromosomes 1p, 1q, 3q, 4q, 6p, 17q, and 19p, respectively. To investigate the …

Background Psoriasis is an immunologically mediated, probably autoimmune, disease in
which T‐helper type 1 cytokines play an important role. Established autoimmune diseases …

Psoriasis is a multifactorial disease with a strong genetic background. It associates strongly
to HLA-Cw* 0602. HLA-C interacts with killer immunoglobulin-like receptors (KIR) on natural …

Background Type 1 T cells are hypothesized to be central in the immunopathogenesis of
psoriasis. Through elaboration of interferon (IFN)‐γ, type 1 T cells regulate the expression of …

The aetiology of psoriasis is still unclear but our knowledge of the psoriatic process has
grown substantially over the last two decades. The future will undoubtedly bring advances in …

The polymorphism of the major histocompatibility complex class I chain-related A gene is
associated with type 1 diabetes mellitus. The major histocompatibility complex class I chain …

Alopecia areata (AA) is characterized by hair loss in patches and may progress to total loss
of scalp hair, or total loss of scalp and body hair. The major histocompatibility complex (HLA) …