During the past 15 years there has developed significant in-terest in the preparation and
investigation of phosphonic acids and their derivatives which might be considered to be …

Some influences of fluorine in bioorganic chemistry Page 1 O O R′′ R O O R′′ R O O R′′
R HO O R′′ R 1 R = R′′ = H mp = 72 C 2 R = H, R′′ = F mp = 73 C 3 R = R′′ = F mp …

The synthesis of the cyclohexylammonium salts of (1RS, 3S)-3, 4-dihydroxy-1-
fluorobutylphosphonic acid 3 and (S)-difluoro-3, 4-dihydroxybutylphosphonic acid 4 is …

The organometallic reagent,(EtO) 2P (O) CFHZnBr, was generated in situ in excellent yields
via the reaction of (EtO) 2P (O) CFHBr with zinc metal. Metathesis with Cu (I) Br gave (EtO) …

The synthesis of the cyclohexylammonium salts of 3-(S), 4-dihydroxy-1 (R, S)-
fluorobutylphosphonic acid 3 and 1, 1-difluoro-3-(S), 4-dihydroxybutylphosphonic acid 4 is …

Abstract S-(+)-3, 4-Dihydroxybutylphosphonic acid, an isosteric analogue of sn-glycerol 3-
phosphate, was synthesized stereospecifically and shown to be an effective substrate for …

Analogues of dihydroxyacetone phosphate and of 3-phosphoglycerate were made in which
the phosphate group,–O–PO3H2, is replaced by the phosphonomethyl group,–CH2 …

Phosphonate and homophosphonate analogues of 3-deoxy-D-arabino heptulosonate 7-
phosphate and D-gluco heptulosonate 7-phosphate behave as competitive inhibitors of 3 …

An efficient four step synthesis of the title compound 4-hydroxy-3-oxobutylphosphonate (2)
has been developed based on inexpensive 4-ethoxy-1-hydroxybutane-2-one using an …

We have synthesized a pair of diastereoisomers of 1, 3, 4-trihydroxybutyl-1-phosphonic acid.
Both bear the same absolute configuration as sn-glycerol 3-phosphate at the 3-position, but …