Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

Epithelial-mesenchymal transition (EMT) is described as the process in which injured renal
tubular epithelial cells undergo a phenotype change, acquiring mesenchymal characteristics …

The inherent plasticity and resiliency of fibroblasts make this cell type a conventional tool for
basic research. But where do they come from, are all fibroblasts the same, and how do they …

Chronic kidney disease (CKD), defined as the presence of irreversible structural or
functional kidney damages, increases the risk of poor outcomes due to its association with …

microRNAs (miRNAs) are small, non-coding nucleotides that regulate diverse biological
processes. Altered microRNA biosynthesis or regulation contributes to pathological …

MicroRNAs (miRNAs) belong to a class of endogenous small noncoding RNAs that regulate
gene expression at the posttranscriptional level, through both translational repression and …

Renal fibrosis is at the core of various renal diseases, including diabetic kidney disease
(DKD). Long noncoding RNAs (lncRNAs) are known players in the regulation of renal …

Diabetic nephropathy (DN) is a major cause of morbidity and mortality in diabetes and is the
most common cause of end stage renal disease (ESRD). Renal fibrosis is the final …

Argonaute (Ago) proteins play a central role in post-transcriptional gene regulation through
RNA interference (RNAi). Agos bind small RNAs (sRNAs) including small interfering RNAs …

Background Cyclophosphamide (CP) is a widely used chemotherapeutic drug. However, the
associated nephrotoxicity restricts its clinical use. Aim The present research was designed to …