Mycobacterium tuberculosis uses sophisticated secretion systems, named 6 kDa early
secretory antigenic target (ESAT6) protein family secretion (ESX) systems (also known as …

Bacterial capsules have evolved to be at the forefront of the cell envelope, making them an
essential element of bacterial biology. Efforts to understand the Mycobacterium tuberculosis …

Mycobacterium tuberculosis and Mycobacterium leprae have remained, for many years, the
primary species of the genus Mycobacterium of clinical and microbiological interest. The …

Mycobacterium tuberculosis (Mtb) uses efficient strategies to evade the eradication by
professional phagocytes, involving—as recently confirmed—escape from phagosomal …

Lack of access to human tissues with untreated tuberculosis (TB) has forced generations of
researchers to use animal models and to adopt a paradigm that granulomas are the …

Tuberculosis (TB) remains a major global health threat. Urgent needs in the fight against TB
include improved and innovative treatment options for drug-sensitive and-resistant TB as …

The inflammasome complex is important for host defense against intracellular bacterial
infections. Mycobacterium tuberculosis (Mtb) is a facultative intracellular bacterium which is …

Recent insights into the mechanisms by which Mycobacterium tuberculosis, the etiologic
agent of human tuberculosis, is recognized by cytosolic nucleotide sensors have opened …

Mycobacterium tuberculosis (Mtb) is a very successful pathogen, strictly adapted to humans
and the cause of tuberculosis. Its success is associated with its ability to inhibit host cell …

Background Type VII protein secretion (T7SS) is a specialised system for excreting
extracellular proteins across bacterial cell membranes and has been associated with …