Toxicology of cadmium and its damage to mammalian organs

F Thévenod, WK Lee - Cadmium: from toxicity to essentiality, 2013 - Springer
The detrimental health effects of cadmium (Cd) were first described in the mid 19th century.
As part of industrial developments, increasing usage of Cd has led to widespread …

The hypothalamic–pituitary–gonadal axis is target of cadmium toxicity. An update of recent studies and potential therapeutic approaches

A Lafuente - Food and chemical toxicology, 2013 - Elsevier
This review presents an overview of neuroendocrine disruption induced by cadmium on the
hypothalamic–pituitary–gonadal (HHG) axis. This review focuses on a number of …

[HTML][HTML] The environment and female reproduction: Potential mechanism of cadmium poisoning to the growth and development of ovarian follicle

J Qu, Q Wang, X Sun, Y Li - Ecotoxicology and environmental safety, 2022 - Elsevier
Cadmium (Cd) is ubiquitous in our environment and can easily bioaccumulate into the
organism after passage through the respiratory and digestive tracts. Long-term exposure to …

Exposure to mixtures of metals and neurodevelopmental outcomes: a multidisciplinary review using an adverse outcome pathway framework

K von Stackelberg, E Guzy, T Chu, BC Henn - Risk Analysis, 2015 - Wiley Online Library
Current risk assessment guidance calls for an individual chemical‐by‐chemical approach
that fails to capture potential interactive effects of exposure to environmental mixtures and …

Comprehensive review of cadmium toxicity mechanisms in male reproduction and therapeutic strategies

L Xiong, B Zhou, H Liu, L Cai - Reviews of Environmental Contamination …, 2021 - Springer
Cadmium (Cd) has been widely studied as an environmental pollutant for many years.
Numerous studies have reported that Cd exposure causes damage to the heart, liver …

Cadmium and reproductive health in women: a systematic review of the epidemiologic evidence

AZ Pollack, S Ranasinghe, LA Sjaarda… - Current environmental …, 2014 - Springer
An evolving body of evidence supports that cadmium, a non-essential heavy metal, may be
associated with multiple adverse women's reproductive health outcomes. Our objective was …

Modulation of steroidogenic pathway in rat granulosa cells with subclinical Cd exposure and insulin resistance: an impact on female fertility

M Belani, N Purohit, P Pillai, S Gupta… - BioMed research …, 2014 - Wiley Online Library
Changes in lifestyle lead to insulin resistance (IR) in females ultimately predisposing them
towards infertility. In addition, cadmium (Cd), an environmental endocrine disruptor, is …

Cumulative lead exposure and age at menopause in the Nurses' Health Study cohort

KD Eum, MG Weisskopf, LH Nie, H Hu… - Environmental health …, 2014 - ehp.niehs.nih.gov
Background: Early menopause has been associated with many adverse health outcomes,
including increased risk of cardiovascular disease morbidity and mortality. Lead has been …

Dysregulation of intraovarian redox status and steroidogenesis pathway in letrozole-induced PCOS rat model: a possible modulatory role of l-Carnitine

SH Elmosalamy, EMM Elleithy, ZSO Ahmed… - Beni-Suef University …, 2022 - Springer
Background Polycystic ovarian syndrome (PCOS) is a reproductive disorder associated with
several endocrine and metabolic alterations. The mechanism underlying this syndrome is …

The effects of chronic lifelong activation of the AHR pathway by industrial chemical pollutants on female human reproduction

A Cavallini, C Lippolis, M Vacca, C Nardelli… - PloS one, 2016 - journals.plos.org
Environmental chemicals, such as heavy metals, affect female reproductive function. A
biological sensor of the signals of many toxic chemical compounds seems to be the aryl …