Traumatic brain injury recapitulates developmental changes of axons
During development, half of brain white matter axons are maintained for growth, while the
remainder undergo developmental axon degeneration. After traumatic brain injury (TBI) …
remainder undergo developmental axon degeneration. After traumatic brain injury (TBI) …
Optogenetic stimulation of CA1 pyramidal neurons at theta enhances recognition memory in brain injured animals
JI Broussard, JB Redell, J Zhao, R West… - Journal of …, 2023 - liebertpub.com
The hippocampus plays a prominent role in learning and memory formation. The functional
integrity of this structure is often compromised after traumatic brain injury (TBI), resulting in …
integrity of this structure is often compromised after traumatic brain injury (TBI), resulting in …
Detection and verification of neurodegeneration after traumatic brain injury in the mouse: immunohistochemical staining for amyloid precursor protein
G Xiong, H Metheny, K Hood, I Jean… - Brain …, 2023 - Wiley Online Library
Previous studies of human traumatic brain injury (TBI) have shown diffuse axonal injury as
varicosities or spheroids in white matter (WM) bundles when using immunoperoxidase‐ABC …
varicosities or spheroids in white matter (WM) bundles when using immunoperoxidase‐ABC …
Emerging Approaches for Regenerative Rehabilitation Following Traumatic Brain Injury: Regenerative Rehabilitation in TBI
The potential for rehabilitation to improve recovery after traumatic brain injury (TBI) is limited
by a lack of inherent regenerative capacity in the brain as well as the chronic disabilities and …
by a lack of inherent regenerative capacity in the brain as well as the chronic disabilities and …
High-Frequency Head Impact Disrupts Hippocampal Neural Ensemble Dynamics
DP Chapman, SS Sloley, AP Caccavano… - Frontiers in Cellular …, 2022 - frontiersin.org
We have recently shown that the cognitive impairments in a mouse model of high-frequency
head impact (HFHI) are caused by chronic changes to synaptic physiology. To better …
head impact (HFHI) are caused by chronic changes to synaptic physiology. To better …
Temporal and structural sensitivities of major biomarkers for detecting neuropathology after traumatic brain injury in the mouse
G Xiong, I Jean, AM Farrugia, H Metheny… - Frontiers in …, 2024 - frontiersin.org
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality, especially in
teenagers to young adults. In recent decades, different biomarkers and/or staining protocols …
teenagers to young adults. In recent decades, different biomarkers and/or staining protocols …
Mild Traumatic Brain Injury Impairs Coupling of CA1 Neuronal Activity to Theta Oscillations
B Noble, R Homma, JI Broussard, D Robinson… - Neurotrauma …, 2024 - liebertpub.com
Mild traumatic brain injury (mTBI) is the most prevalent form of brain injury, and persons
sustaining an mTBI can experience a number of neurological and behavioral impairments …
sustaining an mTBI can experience a number of neurological and behavioral impairments …
Hippocampal interneuronal dysfunction and hyperexcitability in a porcine model of concussion
Cognitive impairment is a common symptom following mild traumatic brain injury (mTBI or
concussion) and can persist for years in some individuals. Hippocampal slice preparations …
concussion) and can persist for years in some individuals. Hippocampal slice preparations …
Peering into the Brain through the Retrosplenial Cortex to Assess Cognitive Function of the Injured Brain
The retrosplenial cortex (RSC) is a posterior cortical area that has been drawing increasing
interest in recent years, with a growing number of studies studying its contribution to …
interest in recent years, with a growing number of studies studying its contribution to …
Disrupted Hippocampal Theta-Gamma Coupling and Spike-Field Coherence Following Experimental Traumatic Brain Injury
Traumatic brain injury (TBI) often results in persistent learning and memory deficits, likely
due to disrupted hippocampal circuitry underlying these processes. Precise temporal control …
due to disrupted hippocampal circuitry underlying these processes. Precise temporal control …