Traumatic brain injury recapitulates developmental changes of axons

H Song, C Chen, B Kelley, A Tomasevich, H Lee… - Progress in …, 2022 - Elsevier
During development, half of brain white matter axons are maintained for growth, while the
remainder undergo developmental axon degeneration. After traumatic brain injury (TBI) …

Optogenetic stimulation of CA1 pyramidal neurons at theta enhances recognition memory in brain injured animals

JI Broussard, JB Redell, J Zhao, R West… - Journal of …, 2023 - liebertpub.com
The hippocampus plays a prominent role in learning and memory formation. The functional
integrity of this structure is often compromised after traumatic brain injury (TBI), resulting in …

Detection and verification of neurodegeneration after traumatic brain injury in the mouse: immunohistochemical staining for amyloid precursor protein

G Xiong, H Metheny, K Hood, I Jean… - Brain …, 2023 - Wiley Online Library
Previous studies of human traumatic brain injury (TBI) have shown diffuse axonal injury as
varicosities or spheroids in white matter (WM) bundles when using immunoperoxidase‐ABC …

Emerging Approaches for Regenerative Rehabilitation Following Traumatic Brain Injury: Regenerative Rehabilitation in TBI

JC O'Donnell, RL Swanson, KL Wofford… - … : From Basic Science to …, 2022 - Springer
The potential for rehabilitation to improve recovery after traumatic brain injury (TBI) is limited
by a lack of inherent regenerative capacity in the brain as well as the chronic disabilities and …

High-Frequency Head Impact Disrupts Hippocampal Neural Ensemble Dynamics

DP Chapman, SS Sloley, AP Caccavano… - Frontiers in Cellular …, 2022 - frontiersin.org
We have recently shown that the cognitive impairments in a mouse model of high-frequency
head impact (HFHI) are caused by chronic changes to synaptic physiology. To better …

Temporal and structural sensitivities of major biomarkers for detecting neuropathology after traumatic brain injury in the mouse

G Xiong, I Jean, AM Farrugia, H Metheny… - Frontiers in …, 2024 - frontiersin.org
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality, especially in
teenagers to young adults. In recent decades, different biomarkers and/or staining protocols …

Mild Traumatic Brain Injury Impairs Coupling of CA1 Neuronal Activity to Theta Oscillations

B Noble, R Homma, JI Broussard, D Robinson… - Neurotrauma …, 2024 - liebertpub.com
Mild traumatic brain injury (mTBI) is the most prevalent form of brain injury, and persons
sustaining an mTBI can experience a number of neurological and behavioral impairments …

Hippocampal interneuronal dysfunction and hyperexcitability in a porcine model of concussion

AV Ulyanova, CD Adam, C Cottone… - Communications …, 2023 - nature.com
Cognitive impairment is a common symptom following mild traumatic brain injury (mTBI or
concussion) and can persist for years in some individuals. Hippocampal slice preparations …

Peering into the Brain through the Retrosplenial Cortex to Assess Cognitive Function of the Injured Brain

H Motanis, LN Khorasani, CC Giza… - Neurotrauma Reports, 2021 - liebertpub.com
The retrosplenial cortex (RSC) is a posterior cortical area that has been drawing increasing
interest in recent years, with a growing number of studies studying its contribution to …

Disrupted Hippocampal Theta-Gamma Coupling and Spike-Field Coherence Following Experimental Traumatic Brain Injury

CD Adam, E Mirzakhalili, KG Gagnon, C Cottone… - bioRxiv, 2024 - biorxiv.org
Traumatic brain injury (TBI) often results in persistent learning and memory deficits, likely
due to disrupted hippocampal circuitry underlying these processes. Precise temporal control …