Anhedonia is described as a decreased ability to experience rewarding and enjoyable
activities, a core symptom of major depressive disorder. The sucrose preference test (SPT) is …

Ethanol (EtOH) has effects on numerous cellular molecular targets, and alterations in
synaptic function are prominent among these effects. Acute exposure to EtOH activates or …

Chronic alcohol consumption and withdrawal leads to anxiety, escalated alcohol drinking
behavior, and alcohol dependence. Alterations in the function of key structures within the …

Repeated, extreme, or traumatic stressors can elicit pathological effects leading to many
negative physical and psychological outcomes. Stressors can precipitate the onset of …

While anxiety disorders are the brain disorders with the highest prevalence and constitute a
major burden for society, a considerable number of affected people are still treated …

The neuropeptide Y (NPY) system is emerging as a promising therapeutic target for
neuropsychiatric disorders by intranasal delivery to the brain. However, the vast majority of …

Posttraumatic stress disorder (PTSD) is a trauma-evoked syndrome, with variable
prevalence within the human population due to individual differences in coping and …

Alcohol use disorder (AUD) affects all sexes, however women who develop AUD may be
particularly susceptible to cravings and other components of the disease. While many brain …

Anhedonia is the decreased ability to experience pleasure from rewarding or enjoyable
activities, a core symptom of depression. The sucrose preference test (SPT), based on a two …

More effective treatments for fentanyl use disorder are urgently needed. An emerging
literature indicates that glucagon-like peptide-1 receptor (GLP-1R) agonists attenuate …