Fluorine-containing amino acids are becoming increasingly prominent in new drugs due to
two general trends in the modern pharmaceutical industry. Firstly, the growing acceptance of …

Herein we report on the well-documented, yet not widely known, phenomenon of the self-
disproportionation of enantiomers (SDE): the spontaneous fractionation of scalemic material …

B (OCH2CF3) 3, prepared from readily available B2O3 and 2, 2, 2-trifluoroethanol, is as an
effective reagent for the direct amidation of a variety of carboxylic acids with a broad range of …

A highly improved and green methodology for the direct amidation of carboxylic acids with
amines using silica gel as a solid support and catalyst is described. The scope of this …

Novel cinchona alkaloid derived chiral phase‐transfer catalysts enabled the highly chemo‐,
regio‐, diastereo‐, and enantioselective umpolung addition of trifluoromethyl imines to α, β …

Organocatalytic Asymmetric Biomimetic Transamination: From α-Keto Esters to Optically Active
α-Amino Acid Derivatives | Journal of the American Chemical Society ACS ACS Publications …

The biomimetic transamination of fluorinated carbonyl compounds, represent the most
methodologically concise and generalized approach to the family of fluorine-containing …

The major goal of this review is to provide an overview of the general synthetic methods
available in the literature for preparing fluorinated β-amino acids and their derivatives …

Naturally occurring compounds containing a CF bond are extremely rare; only a handful of
fluorine-containing carboxylic acids have been described so far. By contrast, man-made …

The CF3 group attached to N-aryl hydrazone could be activated upon treatment with a
suitable base, thus serving as an excellent C1 unit for the assembly of a series of 1, 3, 4 …