The NOD mouse: a model of immune dysregulation
MS Anderson, JA Bluestone - Annu. Rev. Immunol., 2005 - annualreviews.org
▪ Abstract Autoimmunity is a complex process that likely results from the summation of
multiple defective tolerance mechanisms. The NOD mouse strain is an excellent model of …
multiple defective tolerance mechanisms. The NOD mouse strain is an excellent model of …
Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation
B Salomon, JA Bluestone - Annual review of immunology, 2001 - annualreviews.org
Recent advances in the understanding of T cell activation have led to new therapeutic
approaches in the treatment of immunological disorders. One attractive target of intervention …
approaches in the treatment of immunological disorders. One attractive target of intervention …
Differential T cell costimulatory requirements in CD28-deficient mice
A Shahinian, K Pfeffer, KP Lee, TM Kündig, K Kishihara… - Science, 1993 - science.org
T cell receptor stimulation without costimulation is insufficient for the induction of an optimal
immune response. It is thought that engagement of the CD28 molecule with its ligand B7 …
immune response. It is thought that engagement of the CD28 molecule with its ligand B7 …
B70 antigen is a second ligand for CTLA-4 and CD28
M Azuma, D Ito, H Yagita, K Okumura, JH Phillips… - Nature, 1993 - nature.com
Abstract THE membrane antigen B7/BB1 (refs 1, 2) is expressed on activated B cells,
macrophages and dendritic cells, and binds to a counter-receptor, CD28, expressed on T …
macrophages and dendritic cells, and binds to a counter-receptor, CD28, expressed on T …
Premature ovarian failure and ovarian autoimmunity
A Hoek, J Schoemaker, HA Drexhage - Endocrine reviews, 1997 - academic.oup.com
Premature Ovarian Failure and Ovarian Autoimmunity* | Endocrine Reviews | Oxford
Academic Skip to Main Content Advertisement Oxford Academic Journals Books Search …
Academic Skip to Main Content Advertisement Oxford Academic Journals Books Search …
Treatment of murine lupus with CTLA4Ig
BK Finck, PS Linsley, D Wofsy - Science, 1994 - science.org
The interaction of B7-related molecules on antigen-presenting cells with CD28 or CTLA-4
antigens on T cells provides a second signal for T cell activation. Selective inhibition of the …
antigens on T cells provides a second signal for T cell activation. Selective inhibition of the …
Regulation of surface and intracellular expression of CTLA4 on mouse T cells.
ML Alegre, PJ Noel, BJ Eisfelder, E Chuang… - … (Baltimore, Md.: 1950 …, 1996 - journals.aai.org
CTLA4 is a cell surface molecule that shares 30% homology with CD28 and binds B7 family
members with high affinity. Analysis of surface expression on murine T cells revealed up …
members with high affinity. Analysis of surface expression on murine T cells revealed up …
CD28-T lymphocytes. Antigenic and functional properties.
A subset of CD8+ alpha beta-TCR/CD3+ T lymphocytes in adult human peripheral blood
lacks expression of CD28, a membrane receptor for the B7/BB1 B cell differentiation Ag that …
lacks expression of CD28, a membrane receptor for the B7/BB1 B cell differentiation Ag that …
Genome‐wide analysis of mRNA decay in resting and activated primary human T lymphocytes
A Raghavan, RL Ogilvie, C Reilly… - Nucleic acids …, 2002 - academic.oup.com
We used microarray technology to measure mRNA decay rates in resting and activated T
lymphocytes in order to better understand the role of mRNA decay in regulating gene …
lymphocytes in order to better understand the role of mRNA decay in regulating gene …
Functional expression of B7/BB1 on activated T lymphocytes.
B7/BB1 is a membrane differentiation antigen expressed on activated B cells, macrophages,
and dendritic cells that binds to a counter-receptor, CD28, expressed on T lymphocytes and …
and dendritic cells that binds to a counter-receptor, CD28, expressed on T lymphocytes and …