Preventing human-to-mosquito transmission of malaria parasites provides possible
solutions to interrupt the malaria parasite life cycle for malaria elimination. The development …

Background Analysis of the varied developmental pathways exploited by malarial parasites
as they pass through their differing life stages can be challenging [1–3], the parasites often …

A major cause of the paucity of new starting points for drug discovery is the lack of
interaction between academia and industry. Much of the global resource in biology is …

As part of the global effort toward malaria eradication, phenotypic whole-cell screening
revealed the 2-aminopyridine class of small molecules as a good starting point to develop …

Preventing transmission is an important element of malaria control. However, most of the
current available methods to assay for malaria transmission blocking are relatively low …

The malaria parasite Plasmodium falciparum replicates inside erythrocytes in the blood of
infected humans. During each replication cycle, a small proportion of parasites commits to …

The threat of widespread drug resistance to frontline antimalarials has renewed the urgency
for identifying inexpensive chemotherapeutic compounds that are effective against …

Chemical matter is needed to target the divergent biology associated with the different life
cycle stages of Plasmodium. Here, we report the parallel de novo screening of the …

Background Malaria pathogenesis relies on sexual gametocyte forms of the malaria parasite
to be transmitted between the infected human and the mosquito host but the molecular …

Presently, artemisinin-based combination therapy (ACT) is the first-line therapy of
Plasmodium falciparum malaria. With the emergence of malaria parasites that are resistant …