Many human brain disorders are associated with characteristic alterations in the structural
and functional connectivity of the brain. In this article, we explore how commonalities and …

Opioids are powerful drugs that usurp and overpower the reward function of endogenous
opioids and engage dramatic tolerance and withdrawal via molecular and neurocircuitry …

Compulsive drug seeking that is associated with addiction is hypothesized to follow a
heuristic framework that involves three stages (binge/intoxication, withdrawal/negative affect …

Drug addiction is a worldwide societal problem and public health burden, and results from
recreational drug use that develops into a complex brain disorder. The opioid system, one of …

Preclinical applications of resting-state functional magnetic resonance imaging (rsfMRI) offer
the possibility to non-invasively probe whole-brain network dynamics and to investigate the …

Slow response to the standard treatment for depression increases suffering and risk of
suicide. Ketamine, an N-methyl-d-aspartate (NMDA) receptor antagonist, can rapidly …

Neuroscience studies are often carried out in animal models for the purpose of
understanding specific aspects of the human condition. However, the translation of findings …

Addiction is a disease characterized by compulsive drug seeking and consumption
observed in 20–30% of users. An addicted individual will favor drug reward over natural …

Opioid misuse and addiction are a public health crisis resulting in debilitation, deaths, and
significant social and economic impact. Curbing this crisis requires collaboration among …

Major depressive disorder (MDD) is a devastating mental disorder that affects up to 17% of
the population worldwide. Although brain-wide network-level abnormalities in MDD patients …