Hypertension is the single most important risk factor for cardiovascular disease and, thus,
remains a global public health challenge. Significant progress has been made during the …

Essential hypertension is a multifactorial disorder with a strong genetic predisposition.
Although anti-hypertensive medications have drastically reduced cardiovascular diseases …

purpose. To quantify and evaluate the distribution of angiotensin II (Ang II) and its receptors
in the human retina. methods. Donor eyes were obtained within 12 hours postmortem and …

Pancreatic cancer is a deadly disease that is largely resistant to immunotherapy, in part
because of the accumulation of immunosuppressive cells in the tumor microenvironment …

Abstract Aims Angiotensin II (Ang II) has been shown to have both central and peripheral
effects in mediating hypertension, for which the hypothalamic paraventricular nucleus (PVN) …

Hypertension is considered a low-grade inflammatory condition, and understanding the role
of transcription factors in guiding this response is pertinent. A prominent transcription factor …

Introduction: Macrophage migration inhibitory factor (MIF) has emerged as a promising drug
target in diseases including sepsis, rheumatoid arthritis, and cancer. MIF has multiple …

Parkinson's disease (PD) is a progressive neurodegenerative condition that
pathognomonically involves the death of dopaminergic neurons in the substantia nigra pars …

OBJECTIVE—Pathogenic mechanisms underlying diabetes-induced retinal dysfunction are
not fully understood. The aim of the present study was to show the relationship of the renin …

Macrophage migration inhibitory factor (MIF) is a multifunctional protein that exhibits an
intrinsic thiol protein oxidoreductase activity and proinflammatory activities. In the present …