Long noncoding RNAs (lncRNAs) are sequences of 200 nucleotides or more that are
transcribed from a large portion of the mammalian genome. While hypothesized to have a …

Circular RNAs (circRNAs) are a novel class of RNAs distinguished by their single-stranded,
covalently-closed topology. Although initially perceived as rare byproducts of aberrant …

CircRNAs are a class of single-stranded RNAs with covalently linked head-to-tail topology.
In the decades since its initial discovery, their biogenesis, regulation, and function have …

Circular RNAs (circRNAs) are highly stable RNA molecules that are attractive templates for
expression of therapeutic proteins and non-coding RNAs. In eukaryotes, circRNAs are …

Circular RNAs (circRNAs) are long-lived, covalently closed RNAs that are abundantly
expressed and evolutionarily conserved across eukaryotes. Possible functions ranging from …

Regulated transgene expression is an integral component of gene therapies, cell therapies
and biomanufacturing. However, transcription factor-based regulation, upon which most …

Circular RNAs (circRNAs) are a class of non‑coding RNAs that are generated via alternative
back‑splicing, which connects the terminal 5'and 3'ends. Due to their unique loop structure …

Circular RNAs (circRNAs) are single-stranded, endogenous, non-coding RNA (ncRNA)
molecules formed by the backsplicing of messenger RNA (mRNA) precursors and have …

The circular RNA renaissance is upon us. Recent reports demonstrate applications of
synthetic circular RNA molecules as gene therapies and in the production of biologics from …

Low back pain (LBP) is a major public health problem worldwide and a significant health
and economic burden. Intervertebral disc degeneration (IDD) is the reason for LBP …