Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Tightly orchestrated programmed cell death (PCD) signalling events occur during normal
neuronal development in a spatially and temporally restricted manner to establish the neural …

Alzheimer's disease and related dementias (ADRD) are among the top contributors to
disability and mortality in later life. As with many chronic conditions, aging is the single most …

Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its …

Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …

Background The homeostasis of metal ions, such as iron, copper, zinc and calcium, in the
brain is crucial for maintaining normal physiological functions. Studies have shown that …

Autophagy is a highly conserved catabolic process induced under various conditions of
cellular stress, which prevents cell damage and promotes survival in the event of energy or …

Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …

Autophagy is a catabolic process for unnecessary or dysfunctional cytoplasmic contents by
lysosomal degradation pathways. Autophagy is implicated in various biological processes …