BACKGROUND: Two competing concepts address the development of involvement with
psychoactive substances: the “gateway hypothesis”(GH) and common liability to addiction …

The mesolimbic dopaminergic (ML-DA) system has been recognized for its central role in
motivated behaviors, various types of reward, and, more recently, in cognitive processes …

OBJECTIVE: This longitudinal study had three aims: 1) determine the extent to which boys at
high average risk and low average risk for substance use disorder differ on a construct of …

Pathological alcohol use is a complex and costly problem. This chapter focuses on recent
developments in the etiology of alcohol use disorders. Literature is reviewed from the fields …

Background: Based on the prevalence and health implications of tobacco and cannabis use,
aiming to reduce their use, especially among youth, is a sound objective at both the …

Research clearly shows that both nature and nurture play important roles in the genesis of
psychopathology. In this paper, we focus on'gene-environment interaction'in mental …

Aim To estimate the general and racial/ethnic specific cumulative probability of remission
from nicotine alcohol cannabis or cocaine dependence, and to identify predictors of …

The empirical literature pertaining to the prevalence, origins, and consequences of
neglectful parenting as it relates to substance abuse is critically reviewed. Available …

Objective: The development of substance use disorder (SUD) was prospectively
investigated in 66 boys having fathers with SUD and 104 boys having fathers with no adult …

Antisocial behavior and substance misuse are forms of problem behavior demonstrating
considerable continuity over time. Accordingly, problem behavior influences interpersonal …