Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important
functions in the regulation of growth and survival of certain cell types during embryonal …

For about four decades, platelet-derived growth factors (PDGF) and their receptors have
been the subject of intense research, revealing their roles in embryo development and …

Platelet‐derived growth factor (PDGF) isoforms and their receptors have important roles
during embryogenesis, particularly in the development of various mesenchymal cell types in …

Introduction. Colorectal cancer (CRC) is an important cause of morbidity and mortality
worldwide. Angiogenesis was reported as one important mechanism activated in colorectal …

Infantile myofibromatosis is one of the most prevalent soft tissue tumors of infancy and
childhood. Multifocal nodules with visceral lesions are associated with a poor prognosis. A …

A large number of alterations in genes encoding receptor tyrosine kinase (RTK), namely
FLT3, c-KIT, platelet-derived growth factor (PDGF) receptors, fibroblast growth factor (FGF) …

Recently, germline and somatic heterozygous mutations in the platelet-derived growth factor
receptor β (PDGFRB) have been associated with familial infantile myofibromatosis (IM) …

Introduction• Tyrosine kinase inhibitors• Fusion gene structure and expression• Loss of wild‐
type alleles• Oligomerization triggers TK activation• Inhibitory domain deletion• Signalling …

Platelet-derived growth factors (PDGF) bind to two closely related receptor tyrosine kinases,
PDGF receptor α and β, which are encoded by the PDGFRA and PDGFRB genes. Aberrant …

Inherited vascular malformations are commonly autosomal dominantly inherited with high,
but incomplete, penetrance; they often present as multiple lesions. We hypothesized that …