This account of the mechanisms of scleroderma highlights the genetic and molecular
changes that cause the vascular changes and fibrosis in the disease. The role of …

ABSTRACT The α1β1, α2β1, α10β1 and α11β1 integrins constitute a subset of the integrin
family with affinity for GFOGER-like sequences in collagens. Integrins α1β1 and α2β1 were …

The balance between matrix metalloproteinases (MMPs) and their inhibitors, the tissue
inhibitors of metalloproteinases (TIMPs), is largely responsible for the remodeling of tissues …

The collagen family of extracellular matrix proteins has played a fundamental role in the
evolution of multicellular animals. At the present, 28 triple helical proteins have been named …

Wound healing is a critical process for the organism. The attempt of this chapter is to
critically summarize the recent advancements in the wound-healing process. Because of the …

In the integrin family, the collagen receptors form a structurally and functionally distinct
subgroup. Two members of this subgroup, α 1 β 1 and α 2 β 1 integrins, are known to bind to …

Significance: Regulation of cell adhesions during tissue repair is fundamentally important for
cell migration, proliferation, and protein production. All cells interact with extracellular matrix …

Polymerization of the ECM proteins fibronectin and laminin has been shown to take place in
close vicinity to the cell surface and be facilitated by β 1 integrins (Lohikangas, L., Gullberg …

Type I and type III procollagen are reduced in photodamaged human skin. This reduction
could result from increased degradation by metalloproteinases and/or from reduced …

Integrin α1β1 is a collagen receptor abundantly expressed on microvascular endothelial
cells. As well as being the only collagen receptor able to activate the Ras/Shc/mitogen …