Immunology for physicists

AS Perelson, G Weisbuch - Reviews of modern physics, 1997 - APS
The immune system is a complex system of cells and molecules that can provide us with a
basic defense against pathogenic organisms. Like the nervous system, the immune system …

Mathematical and computational challenges in population biology and ecosystems science

SA Levin, B Grenfell, A Hastings, AS Perelson - Science, 1997 - science.org
Mathematical and computational approaches provide powerful tools in the study of problems
in population biology and ecosystems science. The subject has a rich history intertwined …

[图书][B] Immunological computation: theory and applications

D Dasgupta, F Nino - 2008 - taylorfrancis.com
Clearly, nature has been very effective in creating organisms that are capable of protecting
themselves against a wide variety of pathogens such as bacteria, fungi, and parasites. The …

[图书][B] Killer cell dynamics: mathematical and computational approaches to immunology

D Wodarz - 2007 - Springer
One of the most complicated organs of higher organisms is the immune system. The function
of the immune system is to fight off pathogenic organisms that enter and grow within the host …

Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts.

M Oprea, AS Perelson - Journal of immunology (Baltimore, Md …, 1997 - journals.aai.org
Although most mutations are deleterious, an interplay between somatic mutation and
selection within germinal centers (GC) results in rapid generation of high affinity memory B …

The immune system as a model for pattern recognition and classification

JH Carter - Journal of the American Medical Informatics …, 2000 - academic.oup.com
Objective: To design a pattern recognition engine based on concepts derived from
mammalian immune systems. Design: A supervised learning system (Immunos-81) was …

Combining cytokine signalling with T-bet and GATA-3 regulation in Th1 and Th2 differentiation: a model for cellular decision-making

A Yates, R Callard, J Stark - Journal of theoretical biology, 2004 - Elsevier
Differentiation of uncommitted T cells into Th1 and Th2 subpopulations depends on both
intracellular events controlling expression of transcription factors T-bet and GATA-3 and …

Cytokine-modulated regulation of helper T cell populations

A Yates, C Bergmann, JL Van Hemmen, J Stark… - Journal of theoretical …, 2000 - Elsevier
Helper T (Th) cells are a crucial component of the adaptive immune system and are of
fundamental importance in orchestrating the appropriate response to pathogenic challenge …

Stability analysis of the immune system induced by chemotaxis

P Zheng, W Shan, G Liao - SIAM Journal on Applied Dynamical Systems, 2023 - SIAM
This paper investigates the stability and instability of a generalized reaction-diffusion-
advection system, which describes a cross-talk between antigens and immune cells via …

[PDF][PDF] Regulation of Th1/Th2 cells in asthma development: a mathematical model

Y Kim, S Lee, YS Kim, S Lawler, YS Gho… - Mathematical …, 2013 - aimsciences.org
Airway exposure levels of lipopolysaccharide (LPS) determine type I versus type II helper T
cell induced experimental asthma. While high LPS levels induce Th1-dominant responses …