Central sensitization represents an enhancement in the function of neurons and circuits in
nociceptive pathways caused by increases in membrane excitability and synaptic efficacy as …

The formation of multiprotein complexes is a repeated theme in biology ranging from the
regulation of the extracellular signal-regulated kinase and cAMP signaling pathways to the …

Information processing in the brain requires multiple forms of synaptic plasticity that
converge on regulation of NMDA and AMPA-type glutamate receptors (NMDAR, AMPAR) …

Activity-dependent changes in excitatory synaptic transmission in the CNS have been
shown to depend on the regulation of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic …

Experience-dependent learning and memory require multiple forms of plasticity at
hippocampal and cortical synapses that are regulated by N-methyl-D-aspartate receptors …

Plasticity at excitatory glutamatergic synapses in the central nervous system is believed to
be critical for neuronal circuits to process and encode information, allowing animals to …

The second messenger cyclic adenosine monophosphate (cAMP), which is produced by
adenylyl cyclases following stimulation of G-protein-coupled receptors, exerts its effect …

Abstract A-Kinase Anchoring Proteins (AKAPs) orchestrate and synchronize cellular events
by tethering the cAMP-dependent protein kinase (PKA) and other signaling enzymes to …

Activity-dependent modification of excitatory synaptic transmission is a fundamental
mechanism for developmental plasticity of the neural circuits and experience-dependent …

The L-type Ca2+ channel Cav1. 2 controls multiple functions throughout the body including
heart rate and neuronal excitability. It is a key mediator of fight-or-flight stress responses …