An updated review on the metabolite (AM404)-mediated central mechanism of action of paracetamol (acetaminophen): experimental evidence and potential clinical …

C Mallet, J Desmeules, R Pegahi… - Journal of Pain …, 2023 - Taylor & Francis
Paracetamol remains the recommended first-line option for mild-to-moderate acute pain in
general population and particularly in vulnerable populations. Despite its wide use, debate …

[HTML][HTML] Pharmacological treatments and therapeutic drug monitoring in patients with chronic pain

F De Rosa, B Giannatiempo, B Charlier, A Coglianese… - Pharmaceutics, 2023 - mdpi.com
Pain is an unpleasant sensory and emotional experience that affects every aspect of a
patient's life and which may be treated through different pharmacological and non …

[HTML][HTML] Deprescribing NSAIDs: The Potential Role of Community Pharmacists

D Amedi, P Gazerani - Pharmacy, 2024 - mdpi.com
Non-steroidal anti-inflammatory drugs (NSAIDs) are largely used for controlling various pain
conditions and are widely available in community pharmacies, with and without prescription …

[HTML][HTML] New perspectives on the adverse effects of NSAIDs in cancer pain: an Italian Delphi study from the Rational Use of Analgesics (RUA) group

G Varrassi, F Coluzzi, D Fornasari, F Fusco… - Journal of Clinical …, 2022 - mdpi.com
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most frequently prescribed
drugs for cancer pain. We used the Delphi methodology to evaluate the opinions of …

[HTML][HTML] Acute ingestion of acetaminophen improves cognitive and repeated high intensity short-term maximal performance in well-trained female athletes: a …

S BenSalem, A Salem, O Boukhris, M Taheri… - European Journal of …, 2024 - Springer
This study examined the effect of acute acetaminophen (ACTP) ingestion on physical
performance during the 5 m shuttle run test (5mSRT), attention, mood states, and the …

[HTML][HTML] Model-Based assessment of the liver safety profile of acetaminophen to support its combination use with topical diclofenac in mild-to-moderate osteoarthritis …

V Sethi, L Qin, IF Trocóniz, L Van der Laan, E Cox… - Pain and Therapy, 2024 - Springer
Introduction The use of combination therapy of oral acetaminophen and topical diclofenac,
having complementary mechanisms of action, is an attractive strategy to enhance the …

[HTML][HTML] Model-Based Meta-Analysis Supporting the Combination of Acetaminophen and Topical Diclofenac in Acute Pain: A Therapy for Mild-to-Moderate …

V Sethi, L Qin, E Cox, IF Trocóniz, O Della Pasqua - Pain and Therapy, 2024 - Springer
Introduction Acetaminophen and topical diclofenac (AtopD) have complementary
mechanisms of action and are therefore candidates for combination use in osteoarthritis …

Supercritical-CO2 mediated preparation of porous carbon from Araucaria heterophylla biomass: A proficient nanomolar detection platform for phenolic water pollutant

SSM Manickaraj, S Pandiyarajan, AH Liao… - Chemosphere, 2024 - Elsevier
aminophenol (AP), an aromatic phenolic compound, is commonly found in commercial
products that eventually enter and pollute environmental water sources. The precise …

[HTML][HTML] Clinical significance of Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio in patients with renal colic

G Yildiz, F Selvi, C Bedel, O Zortuk… - Journal of Preventive and …, 2024 - jpcmed.com
Background: Renal colic is a frequently encountered condition in the emergency department
(ED), characterized by the sudden and severe onset of flank pain. To assess the risk of …

Synthesis of Acetaminophen‐Based Coumarins as Selective COX‐2 Inhibitors: An in vitro‐in silico Study

MHM Jasim, YF Mustafa - Chemistry & Biodiversity, 2024 - Wiley Online Library
Acetaminophen, a centrally‐acting old analgesic drug, is a weak inhibitor of cyclooxygenase
(COX) isoforms with some selectivity toward COX‐2. This compound was used in this work …