Abstract The European Collaborative on Personalized Early Detection and Prevention of
Breast Cancer (ENVISION) brings together several international research consortia working …

DNA double-strand breaks (DSBs) are deleterious DNA lesions that if left unrepaired or are
misrepaired, potentially result in chromosomal aberrations, known drivers of carcinogenesis …

DNA damage/repair constitutes several key pathways working in concert to eliminate DNA
lesions and maintain genome stability and integrity. Defective components in DNA damage …

Ionizing radiation is a well established carcinogen for human cells. At low doses, radiation
exposure mainly results in generation of double strand breaks (DSBs). Radiation-related …

Background Measurement of γ-H2AX foci levels in cells provides a sensitive and reliable
method for quantitation of the radiation-induced DNA damage response. The objective of the …

Cancer risk assessment is a multidisciplinary process that goes beyond the scope of
classical epidemiology to include the biological evaluation of individual differences to …

The immunofluorescence-based detection of γ-H2AX is a reliable and sensitive method for
quantitatively measuring DNA double-strand breaks (DSBs) in irradiated samples. Since …

Although widely known as a tumor suppressor, the breast cancer 1 susceptibility protein
(BRCA1) is also important in development, where it regulates fetal DNA repair pathways that …

Defects in the non-homologous end-joining (NHEJ) DNA repair pathway lead to genomic
instability and carcinogenesis. However, the roles of individual NHEJ genes in …

The use of cell lines or animal models has significant disadvantages when dealing with a set
of heterogeneous diseases such as epithelial ovarian cancer. This has clinical relevance in …