Pain is conventionally viewed as a pattern of convergent activity within the somatosensory
system that represents the exteroceptive sense of touch. Accumulating functional …

▪ Abstract The issue of whether pain is represented by specific neural elements or by
patterned activity within a convergent somatosensory subsystem has been debated for over …

Modern pain-control theory predicts that a loss of inhibition (disinhibition) in the dorsal horn
of the spinal cord is a crucial substrate for chronic pain syndromes. However, the nature of …

Spinal cord injury (SCI) induces incapacitating neuropathic pain in the form of allodynia—a
painful response to normally non‐noxious stimuli. Unfortunately, the underlying mechanisms …

A network of thin (C and Aδ) afferents relays various signals related to the physiological
condition of the body, including sensations of gentle touch, pain, and temperature changes …

Spinal cord stimulation (SCS) is an established and cost-effective therapy for treating severe
chronic pain. However, despite over 40 years of clinical practice and the development of …

Pathophysiology and Treatment Page 1 Neuropathic Pain: Pathophysiology and Treatment Per T*
Hansson Howard L. Fields Raymond G* Hill Paolo Marchettini Editors Progress Pa in Research …

In addition to its involvement in the transmission of neuropathic pain, the dorsal column
system has been shown to have analgesic effects when electrically stimulated. The …

Spinal cord stimulation (SCS) is a clinical therapy for chronic, neuropathic pain, but an
incomplete understanding of the mechanisms underlying SCS contributes to the lack of …

Our previous work indicates that the intrathecal administration of neuropeptide Y (NPY) acts
at its cognate receptors to reduce behavioral signs of nociception in several models of …