The group A streptococcus (GAS) causes a variety of human diseases, including toxic shock
syndrome and necrotizing fasciitis, which are both associated with significant mortality. Even …

In the past decade, advances in microscopic imaging methods, together with the
development of genetically encoded fluorescent reporters, have made it possible to directly …

Many human pathogens produce phenotypic variants as a means to circumvent the host
immune system and enhance survival and, as a potential consequence, exhibit increased …

To colonize and cause disease at distinct anatomical sites, bacterial pathogens must tailor
gene expression in a microenvironment-specific manner. The molecular mechanisms that …

All living organisms communicate with the external environment for their survival and
existence. In prokaryotes, communication is achieved by two‐component systems (TCS) …

Streptococcus mutans is an important etiological agent of dental caries in humans. The
extracellular polysaccharides synthesized by cell-associated glucosyltransferases (encoded …

Phosphorylation relays are a major mechanism by which bacteria alter transcription in
response to environmental signals, but understanding of the functional consequences of …

Streptococcus mutans is known to be resistant to bacitracin, a cyclic polypeptide antibiotic
produced by certain species of the genus Bacillus. This property is often exploited in the …

Control of virulence gene expression in S. pyogenes is under the charge of 13 two-
component regulatory systems and at least 30 transcriptional regulators known thus far …

The CovR/S two‐component system regulates the transcription of many genes that are
crucial for the virulence of Streptococcus pyogenes (group A Streptococcus, GAS) …