Metabolism and regulation of canonical histone mRNAs: life without a poly (A) tail
WF Marzluff, EJ Wagner, RJ Duronio - Nature Reviews Genetics, 2008 - nature.com
The canonical histone proteins are encoded by replication-dependent genes and must
rapidly reach high levels of expression during S phase. In metazoans the genes that encode …
rapidly reach high levels of expression during S phase. In metazoans the genes that encode …
Formation of mRNA 3′ ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis
J Zhao, L Hyman, C Moore - Microbiology and molecular biology …, 1999 - Am Soc Microbiol
Formation of mRNA 3′ ends in eukaryotes requires the interaction of transacting factors
with cis-acting signal elements on the RNA precursor by two distinct mechanisms, one for …
with cis-acting signal elements on the RNA precursor by two distinct mechanisms, one for …
The human and mouse replication-dependent histone genes
WF Marzluff, P Gongidi, KR Woods, J Jin, LJ Maltais - Genomics, 2002 - Elsevier
The multigene family encoding the five classes of replication-dependent histones has been
identified from the human and mouse genome sequence. The large cluster of histone genes …
identified from the human and mouse genome sequence. The large cluster of histone genes …
Cleavage and polyadenylation: Ending the message expands gene regulation
J Neve, R Patel, Z Wang, A Louey, AM Furger - RNA biology, 2017 - Taylor & Francis
Cleavage and polyadenylation (pA) is a fundamental step that is required for the maturation
of primary protein encoding transcripts into functional mRNAs that can be exported from the …
of primary protein encoding transcripts into functional mRNAs that can be exported from the …
H1 histones: current perspectives and challenges
H1 and related linker histones are important both for maintenance of higher-order chromatin
structure and for the regulation of gene expression. The biology of the linker histones is …
structure and for the regulation of gene expression. The biology of the linker histones is …
Histone variants: key players of chromatin
B Biterge, R Schneider - Cell and tissue research, 2014 - Springer
Histones are fundamental structural components of chromatin. Eukaryotic DNA is wound
around an octamer of the core histones H2A, H2B, H3, and H4. Binding of linker histone H1 …
around an octamer of the core histones H2A, H2B, H3, and H4. Binding of linker histone H1 …
3′ end mRNA processing: molecular mechanisms and implications for health and disease
S Danckwardt, MW Hentze, AE Kulozik - The EMBO journal, 2008 - embopress.org
Recent advances in the understanding of the molecular mechanism of mRNA 3′ end
processing have uncovered a previously unanticipated integrated network of transcriptional …
processing have uncovered a previously unanticipated integrated network of transcriptional …
In vitro polyadenylation is stimulated by the presence of an upstream intron.
M Niwa, SD Rose, SM Berget - Genes & development, 1990 - genesdev.cshlp.org
The majority of vertebrate pre-mRNAs are both spliced and polyadenylated. To investigate
the mechanism whereby processing factors recognize last exons containing both splicing …
the mechanism whereby processing factors recognize last exons containing both splicing …
Artificial nucleic acid molecules for improved protein or peptide expression
A Thess - US Patent 9,683,233, 2017 - Google Patents
DBFUQOZREOHGAV-UAKXSSHOSA-N [[(2r, 3s, 4r, 5r)-5-(4-amino-5-bromo-2-oxopyrimidin-
1-yl)-3, 4-dihydroxyoxolan-2-yl] methoxy-hydroxyphosphoryl] phosphono hydrogen …
1-yl)-3, 4-dihydroxyoxolan-2-yl] methoxy-hydroxyphosphoryl] phosphono hydrogen …
Formation of the 3′ end of histone mRNA
Z Dominski, WF Marzluff - Gene, 1999 - Elsevier
All metazoan messenger RNAs, with the exception of the replication-dependent histone
mRNAs, terminate at the 3′ end with a poly (A) tail. Replication-dependent histone mRNAs …
mRNAs, terminate at the 3′ end with a poly (A) tail. Replication-dependent histone mRNAs …