Computational genomics tools for dissecting tumour–immune cell interactions
Recent breakthroughs in cancer immunotherapy and decreasing costs of high-throughput
technologies have sparked intensive research into tumour–immune cell interactions using …
technologies have sparked intensive research into tumour–immune cell interactions using …
[HTML][HTML] T cell repertoire profiling and the mechanism by which HLA-B27 causes ankylosing spondylitis
J Garrido-Mesa, MA Brown - Current rheumatology reports, 2022 - Springer
Abstract Purpose of Review Ankylosing spondylitis (AS) is strongly associated with the HLA-
B27 gene. The canonical function of HLA-B27 is to present antigenic peptides to CD8 …
B27 gene. The canonical function of HLA-B27 is to present antigenic peptides to CD8 …
[HTML][HTML] The autoimmune signature of hyperinflammatory multisystem inflammatory syndrome in children
RA Porritt, A Binek, L Paschold… - The Journal of …, 2021 - Am Soc Clin Investig
Multisystem inflammatory syndrome in children (MIS-C) manifests as a severe and
uncontrolled inflammatory response with multiorgan involvement, occurring weeks after …
uncontrolled inflammatory response with multiorgan involvement, occurring weeks after …
MiXCR: software for comprehensive adaptive immunity profiling
fy this observation, we extracted the maximum of the post-stimulus signal in the five most
responsive regions in both experiments. In 2P imaging, all regions displayed a substantial …
responsive regions in both experiments. In 2P imaging, all regions displayed a substantial …
[HTML][HTML] Overview of methodologies for T-cell receptor repertoire analysis
Background The T-cell receptor (TCR), located on the surface of T cells, is responsible for
the recognition of the antigen-major histocompatibility complex, leading to the initiation of an …
the recognition of the antigen-major histocompatibility complex, leading to the initiation of an …
IMGT®, the international ImMunoGeneTics information system® 25 years on
MP Lefranc, V Giudicelli, P Duroux… - Nucleic acids …, 2015 - academic.oup.com
IMGT®, the international ImMunoGeneTics information system®(http://www. imgt. org) is the
global reference in immunogenetics and immunoinformatics. By its creation in 1989 by …
global reference in immunogenetics and immunoinformatics. By its creation in 1989 by …
[HTML][HTML] Loss of the HVEM tumor suppressor in lymphoma and restoration by modified CAR-T cells
M Boice, D Salloum, F Mourcin, V Sanghvi, R Amin… - Cell, 2016 - cell.com
The HVEM (TNFRSF14) receptor gene is among the most frequently mutated genes in
germinal center lymphomas. We report that loss of HVEM leads to cell-autonomous …
germinal center lymphomas. We report that loss of HVEM leads to cell-autonomous …
[HTML][HTML] tcR: an R package for T cell receptor repertoire advanced data analysis
Abstract Background The Immunoglobulins (IG) and the T cell receptors (TR) play the key
role in antigen recognition during the adaptive immune response. Recent progress in next …
role in antigen recognition during the adaptive immune response. Recent progress in next …
Cervical lymph nodes and ovarian teratomas as germinal centres in NMDA receptor-antibody encephalitis
Autoantibodies against the extracellular domain of the N-methyl-d-aspartate receptor
(NMDAR) NR1 subunit cause a severe and common form of encephalitis. To better …
(NMDAR) NR1 subunit cause a severe and common form of encephalitis. To better …
Bioinformatic and statistical analysis of adaptive immune repertoires
High-throughput sequencing (HTS) of immune repertoires has enabled the quantitative
analysis of adaptive immune responses and offers the potential to revolutionize research in …
analysis of adaptive immune responses and offers the potential to revolutionize research in …