Protein corona, understanding the nanoparticle–protein interactions and future perspectives: A critical review

T Kopac - International Journal of Biological Macromolecules, 2021 - Elsevier
Proteins are biopolymers of highly varied structures taking part in almost all processes
occurring in living cells. When nanoparticles (NPs) interact with proteins in biological …

Hard and soft protein corona of nanomaterials: Analysis and relevance

R García-Álvarez, M Vallet-Regí - Nanomaterials, 2021 - mdpi.com
Upon contact with a biological milieu, nanomaterials tend to interact with biomolecules
present in the media, especially proteins, leading to the formation of the so-called “protein …

Mesoporous silica particles as drug delivery systems—the state of the art in loading methods and the recent progress in analytical techniques for monitoring these …

K Trzeciak, A Chotera-Ouda, II Bak-Sypien… - Pharmaceutics, 2021 - mdpi.com
Conventional administration of drugs is limited by poor water solubility, low permeability,
and mediocre targeting. Safe and effective delivery of drugs and therapeutic agents remains …

Mapping and identification of soft corona proteins at nanoparticles and their impact on cellular association

H Mohammad-Beigi, Y Hayashi, CM Zeuthen… - Nature …, 2020 - nature.com
The current understanding of the biological identity that nanoparticles may acquire in a
given biological milieu is mostly inferred from the hard component of the protein corona …

Scratching the surface of the protein corona: challenging measurements and controversies

PL Latreille, M Le Goas, S Salimi, J Robert… - ACS …, 2022 - ACS Publications
This Review aims to provide a systematic analysis of the literature regarding ongoing
debates in protein corona research. Our goal is to portray the current understanding of two …

Mechanistic understanding of protein Corona formation around nanoparticles: old puzzles and new insights

K Nienhaus, GU Nienhaus - Small, 2023 - Wiley Online Library
Although a wide variety of nanoparticles (NPs) have been engineered for use as disease
markers or drug delivery agents, the number of nanomedicines in clinical use has hitherto …

Understanding the chemical nature of nanoparticle–protein interactions

D Baimanov, R Cai, C Chen - Bioconjugate chemistry, 2019 - ACS Publications
The formation of a protein corona has been considered a pitfall in the clinical translation of
nanomedicines. Hence, interdisciplinary studies on corona characterization are critically …

In vivo protein corona on nanoparticles: does the control of all material parameters orient the biological behavior?

N Singh, C Marets, J Boudon, N Millot, L Saviot… - Nanoscale …, 2021 - pubs.rsc.org
Nanomaterials have a huge potential in research fields from nanomedicine to medical
devices. However, surface modifications of nanoparticles (NPs) and thus of their …

The Janus of Protein Corona on nanoparticles for tumor targeting, immunotherapy and diagnosis

X Wang, W Zhang - Journal of Controlled Release, 2022 - Elsevier
The therapeutics based on nanoparticles (NPs) are considered as the promising strategy for
tumor detection and treatment. However, one of the most challenges is the adsorption of …

In vivo Protein Corona Formation: Characterizations, Effects on Engineered Nanoparticles' Biobehaviors, and Applications

X Bai, J Wang, Q Mu, G Su - Frontiers in bioengineering and …, 2021 - frontiersin.org
Understanding the basic interactions between engineered nanoparticles (ENPs) and
biological systems is essential for evaluating ENPs' safety and developing better …