Many cuts to ruin: a comprehensive update of caspase substrates

U Fischer, RU Jänicke, K Schulze-Osthoff - Cell Death & Differentiation, 2003 - nature.com
Apoptotic cell death is executed by the caspase-mediated cleavage of various vital proteins.
Elucidating the consequences of this endoproteolytic cleavage is crucial for our …

Poly (ADP-ribose) polymerase-1 cleavage during apoptosis: an update

C Soldani, AI Scovassi - Apoptosis, 2002 - Springer
Poly (ADP-ribosylation) is a post-translational modification of proteins playing a crucial role
in many processes, including DNA repair and cell death. The best known poly (ADP …

An alternative, nonapoptotic form of programmed cell death

S Sperandio, I de Belle… - Proceedings of the …, 2000 - National Acad Sciences
The term apoptosis often has been used interchangeably with the term programmed cell
death. Here we describe a form of programmed cell death that is distinct from apoptosis by …

[HTML][HTML] Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response

N Festjens, TV Berghe, P Vandenabeele - Biochimica et Biophysica Acta …, 2006 - Elsevier
Necrosis has long been described as a consequence of physico-chemical stress and thus
accidental and uncontrolled. Recently, it is becoming clear that necrotic cell death is as well …

Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus

I Baumann, W Kolowos, RE Voll, B Manger… - Arthritis & …, 2002 - Wiley Online Library
Objective To investigate the fate of apoptotic cells in the germinal centers (GCs) of patients
with systemic lupus erythematosus (SLE). Methods Lymph node biopsy specimens obtained …

Cell death in the pathogenesis of systemic lupus erythematosus and lupus nephritis

P Mistry, MJ Kaplan - Clinical Immunology, 2017 - Elsevier
Nephritis is one of the most severe complications of systemic lupus erythematosus (SLE).
One key characteristic of lupus nephritis (LN) is the deposition of immune complexes …

How apoptotic cells aid in the removal of their own cold dead bodies

G Wickman, L Julian, MF Olson - Cell Death & Differentiation, 2012 - nature.com
Apoptotic cell clearance facilitates the removal of aged, damaged, infected or dangerous
cells although minimizing perturbation of surrounding tissues, and is a vital process in the …

Characterization of the necrotic cleavage of poly (ADP-ribose) polymerase (PARP-1): implication of lysosomal proteases

S Gobeil, CC Boucher, D Nadeau… - Cell Death & …, 2001 - nature.com
The poly (ADP-ribose) polymerase (PARP-1), a 113 kDa nuclear enzyme, is cleaved in
fragments of 89 and 24 kDa during apoptosis. This cleavage has become a useful hallmark …

Low-temperature plasma treatment induces DNA damage leading to necrotic cell death in primary prostate epithelial cells

AM Hirst, MS Simms, VM Mann, NJ Maitland… - British journal of …, 2015 - nature.com
Background: In recent years, the rapidly advancing field of low-temperature atmospheric
pressure plasmas has shown considerable promise for future translational biomedical …

SLE—a disease of clearance deficiency?

LE Munoz, US Gaipl, S Franz, A Sheriff, RE Voll… - …, 2005 - academic.oup.com
Systemic lupus erythematosus (SLE) is a multifactorial disease and its pathogenesis and
precise aetiology remain unknown. Under physiological conditions, neither apoptotic nor …