Targets of immune escape mechanisms in cancer: basis for development and evolution of cancer immune checkpoint inhibitors

S Dutta, A Ganguly, K Chatterjee, S Spada… - Biology, 2023 - mdpi.com
Simple Summary The tumor immune escape mechanisms are key factors in cancer
progression and metastasis. They are an undeniable hurdle for successful cancer treatment …

[HTML][HTML] Immunometabolic dysfunction of natural killer cells mediated by the hypoxia-CD73 axis in solid tumors

AM Chambers, S Matosevic - Frontiers in molecular biosciences, 2019 - frontiersin.org
NK cell infiltration into solid tumors is often low and is largely represented by the poorly-
cytotoxic CD56bright subset. Numerous studies have demonstrated that CD73 …

Adenosine 2B receptor expression on cancer cells promotes metastasis

D Mittal, D Sinha, D Barkauskas, A Young, M Kalimutho… - Cancer research, 2016 - AACR
Adenosine plays an important role in inflammation and tumor development, progression,
and responses to therapy. We show that an adenosine 2B receptor inhibitor (A2BRi) …

K4Nb6O17/Fe3N/α-Fe2O3/C3N4 as an enhanced visible light-driven quaternary photocatalyst for acetamiprid photodegradation, CO2 reduction, and cancer cells …

M Padervand, S Ghasemi, S Hajiahmadi… - Applied Surface Science, 2021 - Elsevier
A new magnetic quaternary photocatalyst, K 4 Nb 6 O 17/α-Fe 2 O 3/Fe 3 N/gC 3 N 4, was
synthesized via a simple one-step thermal pyrolysis process. The prepared photocatalyst …

CD73–adenosine: a next-generation target in immuno-oncology

D Allard, B Allard, PO Gaudreau, P Chrobak… - Immunotherapy, 2016 - Future Medicine
Cancer immunotherapy has entered in a new era with the development of first-generation
immune checkpoint inhibitors targeting the PD1/PD-L1 and CTLA-4 pathways. In this …

Glutathione in ovarian cancer: a double-edged sword

SC Nunes, J Serpa - International journal of molecular sciences, 2018 - mdpi.com
Glutathione (GSH) has several roles in a cell, such as a reactive oxygen species (ROS)
scavenger, an intervenient in xenobiotics metabolism and a reservoir of cysteine. All of these …

Adenosine and adenosine receptors in the immunopathogenesis and treatment of cancer

MH Kazemi, S Raoofi Mohseni… - Journal of Cellular …, 2018 - Wiley Online Library
Tumor cells overcome anti‐tumor responses in part through immunosuppressive
mechanisms. There are several immune modulatory mechanisms. Among them, adenosine …

Purine-metabolising enzymes and apoptosis in cancer

M Camici, M Garcia-Gil, R Pesi, S Allegrini, MG Tozzi - Cancers, 2019 - mdpi.com
The enzymes of both de novo and salvage pathways for purine nucleotide synthesis are
regulated to meet the demand of nucleic acid precursors during proliferation. Among them …

Targeting A2 adenosine receptors in cancer

D Allard, M Turcotte, J Stagg - Immunology and cell biology, 2017 - Wiley Online Library
Tumor cells use various ways to evade anti‐tumor immune responses. Adenosine, a potent
immunosuppressive metabolite, is often found elevated in the extracellular tumor …

Ag/AgCl@ Tubular g-C3N4 nanostructure as an enhanced visible light photocatalyst for the removal of organic dye compounds and biomedical waste under visible …

M Padervand, S Hajiahmadi - Journal of Photochemistry and Photobiology …, 2022 - Elsevier
Water contamination is a drastic worldwide issue menacing the whole biosphere and
disturbing people lives as long as human health is strongly depended on the drinkable form …