Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …

The basement membrane is a thin but dense, sheet-like specialized type of extracellular
matrix that has remarkably diverse functions tailored to individual tissues and organs. Tightly …

Vascular dysfunction is a hallmark of chronic diseases in elderly. The contribution of the
vasculature to lung repair and fibrosis is not fully understood. Here, we performed an …

With the outbreak of new respiratory viruses and high mortality rates of pulmonary diseases,
physiologically relevant models of human respiratory system are urgently needed to study …

The objective of lung development is to generate an organ of gas exchange that provides
both a thin gas diffusion barrier and a large gas diffusion surface area, which concomitantly …

Acute respiratory distress syndrome is the most severe form of acute lung injury (ALI) and is
associated with significant mortality. Lipopolysaccharide (LPS)-induced injury is a valuable …

Intracerebral haemorrhage and small vessel ischaemic stroke (SVS) are the most acute
manifestations of cerebral small vessel disease, with no established preventive approaches …

The extraordinarily thin alveolar type 1 (AT1) cell constitutes nearly the entire gas exchange
surface and allows passive diffusion of oxygen into the blood stream. Despite such an …

Abstract COL4A1 and COL4A2 are extracellular matrix proteins that form heterotrimers and
are present in nearly all basement membranes in every organ. In the past decade, COL4A1 …

The basement membrane (BM) is a specialized layer of extracellular matrix components that
plays a central role in maintaining lung and kidney functions. Although the composition of …