Evidence for incentive salience sensitization as a pathway to alcohol use disorder
The incentive salience sensitization (ISS) theory of addiction holds that addictive behavior
stems from the ability of drugs to progressively sensitize the brain circuitry that mediates …
stems from the ability of drugs to progressively sensitize the brain circuitry that mediates …
Naltrexone effects on subjective responses to alcohol in the human laboratory: A systematic review and meta‐analysis
Naltrexone (NTX) has been widely studied for the treatment of alcohol use disorder with
overall support for its efficacy. The mechanisms of action of naltrexone are thought to involve …
overall support for its efficacy. The mechanisms of action of naltrexone are thought to involve …
Reward, relief and habit drinking: initial validation of a brief assessment tool
Aims Alcohol use disorder is highly heterogeneous. One approach to understanding this
heterogeneity is the identification of drinker subtypes. A candidate classification consists of …
heterogeneity is the identification of drinker subtypes. A candidate classification consists of …
Subjective response to alcohol as a research domain criterion
Background Individual differences in the subjective experience of the pharmacological
effects of alcohol have long been implicated in the likelihood that one will drink heavily and …
effects of alcohol have long been implicated in the likelihood that one will drink heavily and …
Biobehavioral effects of baclofen in anxious alcohol-dependent individuals: a randomized, double-blind, placebo-controlled, laboratory study
M Farokhnia, ML Schwandt, MR Lee… - Translational …, 2017 - nature.com
Baclofen has been suggested as a potential pharmacotherapy for alcohol use disorder, but
the clinical data are conflicting. Here we investigated the biobehavioral effects of baclofen in …
the clinical data are conflicting. Here we investigated the biobehavioral effects of baclofen in …
Differences in the subjective and motivational properties of alcohol across alcohol use severity: application of a novel translational human laboratory paradigm
Abstract The Allostatic Model proposes that Alcohol Use Disorder (AUD) is associated with a
transition in the motivational structure of alcohol drinking: from positive reinforcement in …
transition in the motivational structure of alcohol drinking: from positive reinforcement in …
Do behavioral pharmacology findings predict clinical trial outcomes? A proof-of-concept in medication development for alcohol use disorder
Behavioral pharmacology paradigms have been used for early efficacy testing of novel
compounds for alcohol use disorder (AUD). However, the degree to which early efficacy in …
compounds for alcohol use disorder (AUD). However, the degree to which early efficacy in …
Alcohol‐induced place conditioning in moderate social drinkers
E Childs, H de Wit - Addiction, 2016 - Wiley Online Library
Aims To test whether non‐dependent drinkers show place preference for a location paired
with alcohol, and to test if the amount of time spent in the alcohol‐paired location is related …
with alcohol, and to test if the amount of time spent in the alcohol‐paired location is related …
Experimental psychopathology paradigms for alcohol use disorders: applications for translational research
S Bujarski, LA Ray - Behaviour research and therapy, 2016 - Elsevier
In spite of high prevalence and disease burden, scientific consensus on the etiology and
treatment of Alcohol Use Disorder (AUD) has yet to be reached. The development and …
treatment of Alcohol Use Disorder (AUD) has yet to be reached. The development and …
The interplay between subjective response to alcohol, craving, and alcohol self‐administration in the human laboratory
Background Despite a rich literature on human laboratory paradigms of subjective response
(SR) to alcohol, craving for alcohol, and alcohol self‐administration, few studies have …
(SR) to alcohol, craving for alcohol, and alcohol self‐administration, few studies have …