A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions
between luminal contents such as the intestinal microbiota, the underlying immune system …

Hepatocytes form a crucially important cell layer that separates sinusoidal blood from the
canalicular bile. They have a uniquely organized polarity with a basal membrane facing liver …

Cholestatic jaundice in infancy affects approximately 1 in every 2500 term infants and is
infrequently recognized by primary providers in the setting of physiologic jaundice …

Bone marrow‐derived mesenchymal stem cell (BM‐MSC) transplantation has been
suggested as an effective therapy for liver cirrhosis. The efficacy and safety of autologous …

Neonatal cholestasis is a potentially life-threatening condition requiring prompt diagnosis.
Mutations in several different genes can cause progressive familial intrahepatic cholestasis …

Bile was recognized by the ancient Greeks as 1 of the 4 humors; its importance is still
recognized in twenty-first century medicine, although maybe only by hepatologists. Bile …

Background Jaundice is a common symptom of inherited or acquired liver diseases or a
manifestation of diseases involving red blood cell metabolism. Recent progress has …

Abstract β‐Catenin, the downstream effector of the Wnt signaling, plays important roles in
hepatic development, regeneration, and tumorigenesis. However, its role at hepatocyte …

Biliary Atresia and other cholestatic childhood diseases are rare conditions affecting the
function and/or anatomy along the canalicular-bile duct continuum, characterised by onset of …

Pediatric hepatocellular carcinoma (HCC) is the second common malignant liver tumor in
children after hepatoblastoma. It differs from the adult HCC in the etiological predisposition …